HEADER    DNA                                     30-JUL-13   4BZT              
TITLE     THE SOLUTION STRUCTURE OF THE MLN 944-D(ATGCAT)2 COMPLEX              
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: DNA;                                                       
COMPND   3 CHAIN: A, B;                                                         
COMPND   4 OTHER_DETAILS: THE DNA CONFORMATION IS IN THE FORM OF B-DNA.         
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 SYNTHETIC: YES;                                                      
SOURCE   3 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT;                            
SOURCE   4 ORGANISM_TAXID: 32630;                                               
SOURCE   5 OTHER_DETAILS: EUROGENTEC                                            
KEYWDS    BIS(PHENAZINE-1-CARBOXAMIDES), DNA, INTERCALATION, DRUG DESIGN,       
KEYWDS   2 ANTICANCER DRUG.                                                     
EXPDTA    SOLUTION NMR                                                          
MDLTYP    MINIMIZED AVERAGE                                                     
AUTHOR    A.SEROBIAN,D.S.THOMAS,G.E.BALL,W.A.DENNY,L.P.G.WAKELIN                
REVDAT   3   03-SEP-14 4BZT    1       JRNL                                     
REVDAT   2   04-SEP-13 4BZT    1       COMPND                                   
REVDAT   1   21-AUG-13 4BZT    0                                                
JRNL        AUTH   A.SEROBIAN,D.S.THOMAS,G.E.BALL,W.A.DENNY,L.P.G.WAKELIN       
JRNL        TITL   THE SOLUTION STRUCTURE OF BIS(PHENAZINE-1-CARBOXAMIDE)-DNA   
JRNL        TITL 2 COMPLEXES: MLN 944 BINDING CORRECTED AND EXTENDED.           
JRNL        REF    BIOPOLYMERS                   V. 101  1099 2014              
JRNL        REFN                   ISSN 0006-3525                               
JRNL        PMID   24898663                                                     
JRNL        DOI    10.1002/BIP.22513                                            
REMARK   2                                                                      
REMARK   2 RESOLUTION. NOT APPLICABLE.                                          
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : AMBER                                                
REMARK   3   AUTHORS     : D.A.CASE,ET.AL.                                      
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 4BZT COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 01-AUG-13.                  
REMARK 100 THE PDBE ID CODE IS EBI-57846.                                       
REMARK 210                                                                      
REMARK 210 EXPERIMENTAL DETAILS                                                 
REMARK 210  EXPERIMENT TYPE                : NMR                                
REMARK 210  TEMPERATURE           (KELVIN) : 288.0                              
REMARK 210  PH                             : 5.0                                
REMARK 210  IONIC STRENGTH                 : 80MM                               
REMARK 210  PRESSURE                       : 1.0 ATM                            
REMARK 210  SAMPLE CONTENTS                : 10% WATER/90% D2O                  
REMARK 210                                                                      
REMARK 210  NMR EXPERIMENTS CONDUCTED      : NOESY, COSY, TOCSY, 31P            
REMARK 210                                   HSQC, 15N HSQC                     
REMARK 210  SPECTROMETER FIELD STRENGTH    : 700 MHZ                            
REMARK 210  SPECTROMETER MODEL             : AVANCE                             
REMARK 210  SPECTROMETER MANUFACTURER      : BRUKER                             
REMARK 210                                                                      
REMARK 210  STRUCTURE DETERMINATION.                                            
REMARK 210   SOFTWARE USED                 : TOPSPIN 3.1                        
REMARK 210   METHOD USED                   : AMBER                              
REMARK 210                                                                      
REMARK 210 CONFORMERS, NUMBER CALCULATED   : 1                                  
REMARK 210 CONFORMERS, NUMBER SUBMITTED    : 1                                  
REMARK 210 CONFORMERS, SELECTION CRITERIA  : DISTANCE RESTRAINTS                
REMARK 210                                                                      
REMARK 210 BEST REPRESENTATIVE CONFORMER IN THIS ENSEMBLE : NULL                
REMARK 210                                                                      
REMARK 210 REMARK: NONE                                                         
REMARK 215                                                                      
REMARK 215 NMR STUDY                                                            
REMARK 215 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM SOLUTION           
REMARK 215 NMR DATA.  PROTEIN DATA BANK CONVENTIONS REQUIRE THAT                
REMARK 215 CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES ON              
REMARK 215 THESE RECORDS ARE MEANINGLESS.                                       
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PQS                                                   
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500     DA A   1   C4  -  C5  -  C6  ANGL. DEV. =  -3.7 DEGREES          
REMARK 500     DA A   1   C5  -  C6  -  N1  ANGL. DEV. =   3.7 DEGREES          
REMARK 500     DA A   1   N1  -  C6  -  N6  ANGL. DEV. =  -5.2 DEGREES          
REMARK 500     DA A   1   O4' -  C1' -  N9  ANGL. DEV. =   1.9 DEGREES          
REMARK 500     DG A   3   O4' -  C1' -  N9  ANGL. DEV. =   2.4 DEGREES          
REMARK 500     DC A   4   O4' -  C1' -  N1  ANGL. DEV. =   1.8 DEGREES          
REMARK 500     DA A   5   C4  -  C5  -  C6  ANGL. DEV. =  -3.6 DEGREES          
REMARK 500     DA A   5   C5  -  C6  -  N1  ANGL. DEV. =   3.4 DEGREES          
REMARK 500     DA A   5   N1  -  C6  -  N6  ANGL. DEV. =  -5.4 DEGREES          
REMARK 500     DA A   5   O4' -  C1' -  N9  ANGL. DEV. =   2.2 DEGREES          
REMARK 500     DT A   6   C6  -  C5  -  C7  ANGL. DEV. =  -3.6 DEGREES          
REMARK 500     DA B   7   C4  -  C5  -  C6  ANGL. DEV. =  -3.4 DEGREES          
REMARK 500     DA B   7   C5  -  C6  -  N1  ANGL. DEV. =   3.5 DEGREES          
REMARK 500     DA B   7   N1  -  C6  -  N6  ANGL. DEV. =  -5.5 DEGREES          
REMARK 500     DA B   7   O4' -  C1' -  N9  ANGL. DEV. =   1.9 DEGREES          
REMARK 500     DT B   8   O4' -  C1' -  N1  ANGL. DEV. =   2.3 DEGREES          
REMARK 500     DG B   9   O4' -  C1' -  N9  ANGL. DEV. =   2.6 DEGREES          
REMARK 500     DC B  10   N3  -  C2  -  O2  ANGL. DEV. =  -4.4 DEGREES          
REMARK 500     DC B  10   N3  -  C4  -  C5  ANGL. DEV. =   2.5 DEGREES          
REMARK 500     DA B  11   C5  -  C6  -  N1  ANGL. DEV. =   3.4 DEGREES          
REMARK 500     DA B  11   N1  -  C6  -  N6  ANGL. DEV. =  -4.4 DEGREES          
REMARK 500     DA B  11   O4' -  C1' -  N9  ANGL. DEV. =   2.8 DEGREES          
REMARK 500     DT B  12   C6  -  C5  -  C7  ANGL. DEV. =  -3.6 DEGREES          
REMARK 500     DT B  12   O4' -  C1' -  N1  ANGL. DEV. =   3.7 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500     DA A   5         0.07    SIDE CHAIN                              
REMARK 500     DT B   8         0.07    SIDE CHAIN                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE XR2 A  13                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 4BZU   RELATED DB: PDB                                   
REMARK 900  SOLUTION STRUCTURE OF THE MLN 944-D(TATGCATA)2                      
REMARK 900  COMPLEX                                                             
REMARK 900 RELATED ID: 4BZV   RELATED DB: PDB                                   
REMARK 900  THE SOLUTION STRUCTURE OF THE MLN 944-D(TACGCGTA)2                  
REMARK 900  COMPLEX                                                             
DBREF  4BZT A    1     6  PDB    4BZT     4BZT             1      6             
DBREF  4BZT B    7    12  PDB    4BZT     4BZT             7     12             
SEQRES   1 A    6   DA  DT  DG  DC  DA  DT                                      
SEQRES   1 B    6   DA  DT  DG  DC  DA  DT                                      
HET    XR2  A  13      80                                                       
HETNAM     XR2 1-METHYL-9-[12-(9-METHYLPHENAZIN-10-IUM-1-YL)                    
HETNAM   2 XR2  -12-OXO-2,11-DIAZA-5,8-DIAZONIADODEC-1-ANOYL]                   
HETNAM   3 XR2  PHENAZIN-10-IUM                                                 
FORMUL   2  XR2    C34 H38 N8 O2 4+                                             
SITE     1 AC1  8  DT A   2   DG A   3   DC A   4   DA A   5                    
SITE     2 AC1  8  DT B   8   DG B   9   DC B  10   DA B  11                    
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
ATOM      1  O5'  DA A   1      23.876  28.178  45.153  1.00  0.00           O  
ATOM      2  C5'  DA A   1      24.051  27.358  44.008  1.00  0.00           C  
ATOM      3  C4'  DA A   1      23.066  27.706  42.880  1.00  0.00           C  
ATOM      4  O4'  DA A   1      23.287  29.038  42.417  1.00  0.00           O  
ATOM      5  C3'  DA A   1      23.274  26.764  41.686  1.00  0.00           C  
ATOM      6  O3'  DA A   1      22.030  26.247  41.234  1.00  0.00           O  
ATOM      7  C2'  DA A   1      23.942  27.659  40.645  1.00  0.00           C  
ATOM      8  C1'  DA A   1      23.372  29.025  41.002  1.00  0.00           C  
ATOM      9  N9   DA A   1      24.235  30.130  40.531  1.00  0.00           N  
ATOM     10  C8   DA A   1      25.387  30.619  41.097  1.00  0.00           C  
ATOM     11  N7   DA A   1      25.905  31.645  40.472  1.00  0.00           N  
ATOM     12  C5   DA A   1      25.012  31.838  39.398  1.00  0.00           C  
ATOM     13  C6   DA A   1      24.893  32.764  38.330  1.00  0.00           C  
ATOM     14  N6   DA A   1      25.692  33.793  38.123  1.00  0.00           N  
ATOM     15  N1   DA A   1      23.897  32.680  37.446  1.00  0.00           N  
ATOM     16  C2   DA A   1      23.012  31.704  37.594  1.00  0.00           C  
ATOM     17  N3   DA A   1      22.979  30.778  38.541  1.00  0.00           N  
ATOM     18  C4   DA A   1      24.010  30.905  39.420  1.00  0.00           C  
ATOM     19  H5'  DA A   1      23.910  26.313  44.293  1.00  0.00           H  
ATOM     20 H5''  DA A   1      25.069  27.478  43.631  1.00  0.00           H  
ATOM     21  H4'  DA A   1      22.044  27.600  43.248  1.00  0.00           H  
ATOM     22  H3'  DA A   1      23.939  25.942  41.960  1.00  0.00           H  
ATOM     23  H2'  DA A   1      25.024  27.643  40.784  1.00  0.00           H  
ATOM     24 H2''  DA A   1      23.682  27.377  39.625  1.00  0.00           H  
ATOM     25  H1'  DA A   1      22.374  29.118  40.560  1.00  0.00           H  
ATOM     26  H8   DA A   1      25.811  30.193  41.999  1.00  0.00           H  
ATOM     27  H61  DA A   1      25.469  34.435  37.369  1.00  0.00           H  
ATOM     28  H62  DA A   1      26.459  33.940  38.752  1.00  0.00           H  
ATOM     29  H2   DA A   1      22.220  31.662  36.858  1.00  0.00           H  
ATOM     30 HO5'  DA A   1      24.759  28.348  45.547  1.00  0.00           H  
ATOM     31  P    DT A   2      21.989  24.978  40.260  1.00  0.00           P  
ATOM     32  OP1  DT A   2      20.713  24.250  40.405  1.00  0.00           O  
ATOM     33  OP2  DT A   2      23.195  24.155  40.447  1.00  0.00           O  
ATOM     34  O5'  DT A   2      22.058  25.526  38.773  1.00  0.00           O  
ATOM     35  C5'  DT A   2      20.891  25.905  38.059  1.00  0.00           C  
ATOM     36  C4'  DT A   2      21.246  26.275  36.617  1.00  0.00           C  
ATOM     37  O4'  DT A   2      22.012  27.467  36.611  1.00  0.00           O  
ATOM     38  C3'  DT A   2      22.062  25.186  35.892  1.00  0.00           C  
ATOM     39  O3'  DT A   2      21.325  24.664  34.791  1.00  0.00           O  
ATOM     40  C2'  DT A   2      23.326  25.937  35.462  1.00  0.00           C  
ATOM     41  C1'  DT A   2      22.887  27.402  35.512  1.00  0.00           C  
ATOM     42  N1   DT A   2      23.989  28.389  35.695  1.00  0.00           N  
ATOM     43  C2   DT A   2      24.048  29.473  34.811  1.00  0.00           C  
ATOM     44  O2   DT A   2      23.257  29.642  33.885  1.00  0.00           O  
ATOM     45  N3   DT A   2      25.073  30.367  34.991  1.00  0.00           N  
ATOM     46  C4   DT A   2      26.057  30.285  35.946  1.00  0.00           C  
ATOM     47  O4   DT A   2      26.927  31.152  35.966  1.00  0.00           O  
ATOM     48  C5   DT A   2      25.941  29.138  36.846  1.00  0.00           C  
ATOM     49  C7   DT A   2      26.961  28.933  37.953  1.00  0.00           C  
ATOM     50  C6   DT A   2      24.921  28.249  36.706  1.00  0.00           C  
ATOM     51  H5'  DT A   2      20.419  26.760  38.546  1.00  0.00           H  
ATOM     52 H5''  DT A   2      20.185  25.074  38.042  1.00  0.00           H  
ATOM     53  H4'  DT A   2      20.325  26.450  36.060  1.00  0.00           H  
ATOM     54  H3'  DT A   2      22.325  24.382  36.583  1.00  0.00           H  
ATOM     55  H2'  DT A   2      24.115  25.729  36.182  1.00  0.00           H  
ATOM     56 H2''  DT A   2      23.657  25.665  34.463  1.00  0.00           H  
ATOM     57  H1'  DT A   2      22.321  27.623  34.602  1.00  0.00           H  
ATOM     58  H3   DT A   2      25.104  31.159  34.363  1.00  0.00           H  
ATOM     59  H71  DT A   2      27.021  29.835  38.562  1.00  0.00           H  
ATOM     60  H72  DT A   2      26.695  28.085  38.584  1.00  0.00           H  
ATOM     61  H73  DT A   2      27.940  28.759  37.508  1.00  0.00           H  
ATOM     62  H6   DT A   2      24.820  27.425  37.399  1.00  0.00           H  
ATOM     63  P    DG A   3      21.778  23.340  34.008  1.00  0.00           P  
ATOM     64  OP1  DG A   3      20.600  22.863  33.246  1.00  0.00           O  
ATOM     65  OP2  DG A   3      22.436  22.415  34.954  1.00  0.00           O  
ATOM     66  O5'  DG A   3      22.862  23.840  32.950  1.00  0.00           O  
ATOM     67  C5'  DG A   3      22.503  24.626  31.819  1.00  0.00           C  
ATOM     68  C4'  DG A   3      23.484  24.420  30.658  1.00  0.00           C  
ATOM     69  O4'  DG A   3      24.665  25.179  30.859  1.00  0.00           O  
ATOM     70  C3'  DG A   3      23.910  22.948  30.471  1.00  0.00           C  
ATOM     71  O3'  DG A   3      23.673  22.482  29.149  1.00  0.00           O  
ATOM     72  C2'  DG A   3      25.408  23.015  30.753  1.00  0.00           C  
ATOM     73  C1'  DG A   3      25.733  24.441  30.308  1.00  0.00           C  
ATOM     74  N9   DG A   3      27.041  25.000  30.746  1.00  0.00           N  
ATOM     75  C8   DG A   3      27.946  24.536  31.673  1.00  0.00           C  
ATOM     76  N7   DG A   3      28.993  25.304  31.845  1.00  0.00           N  
ATOM     77  C5   DG A   3      28.762  26.368  30.961  1.00  0.00           C  
ATOM     78  C6   DG A   3      29.496  27.584  30.707  1.00  0.00           C  
ATOM     79  O6   DG A   3      30.522  28.007  31.254  1.00  0.00           O  
ATOM     80  N1   DG A   3      28.937  28.368  29.718  1.00  0.00           N  
ATOM     81  C2   DG A   3      27.811  28.035  29.043  1.00  0.00           C  
ATOM     82  N2   DG A   3      27.425  28.825  28.085  1.00  0.00           N  
ATOM     83  N3   DG A   3      27.081  26.950  29.267  1.00  0.00           N  
ATOM     84  C4   DG A   3      27.600  26.156  30.251  1.00  0.00           C  
ATOM     85  H5'  DG A   3      22.474  25.681  32.094  1.00  0.00           H  
ATOM     86 H5''  DG A   3      21.515  24.349  31.466  1.00  0.00           H  
ATOM     87  H4'  DG A   3      23.009  24.764  29.738  1.00  0.00           H  
ATOM     88  H3'  DG A   3      23.428  22.283  31.192  1.00  0.00           H  
ATOM     89  H2'  DG A   3      25.575  22.901  31.825  1.00  0.00           H  
ATOM     90 H2''  DG A   3      25.954  22.261  30.191  1.00  0.00           H  
ATOM     91  H1'  DG A   3      25.667  24.507  29.219  1.00  0.00           H  
ATOM     92  H8   DG A   3      27.789  23.621  32.230  1.00  0.00           H  
ATOM     93  H1   DG A   3      29.385  29.244  29.490  1.00  0.00           H  
ATOM     94  H21  DG A   3      27.955  29.665  27.861  1.00  0.00           H  
ATOM     95  H22  DG A   3      26.639  28.521  27.548  1.00  0.00           H  
ATOM     96  P    DC A   4      22.212  22.016  28.699  1.00  0.00           P  
ATOM     97  OP1  DC A   4      21.166  22.796  29.397  1.00  0.00           O  
ATOM     98  OP2  DC A   4      22.146  20.545  28.731  1.00  0.00           O  
ATOM     99  O5'  DC A   4      22.099  22.318  27.141  1.00  0.00           O  
ATOM    100  C5'  DC A   4      22.072  23.626  26.590  1.00  0.00           C  
ATOM    101  C4'  DC A   4      23.374  23.980  25.856  1.00  0.00           C  
ATOM    102  O4'  DC A   4      24.440  24.296  26.731  1.00  0.00           O  
ATOM    103  C3'  DC A   4      23.939  22.861  24.979  1.00  0.00           C  
ATOM    104  O3'  DC A   4      23.301  22.773  23.719  1.00  0.00           O  
ATOM    105  C2'  DC A   4      25.394  23.284  24.815  1.00  0.00           C  
ATOM    106  C1'  DC A   4      25.620  24.296  25.947  1.00  0.00           C  
ATOM    107  N1   DC A   4      26.798  23.973  26.796  1.00  0.00           N  
ATOM    108  C2   DC A   4      27.881  24.859  26.808  1.00  0.00           C  
ATOM    109  O2   DC A   4      27.897  25.860  26.097  1.00  0.00           O  
ATOM    110  N3   DC A   4      28.958  24.622  27.591  1.00  0.00           N  
ATOM    111  C4   DC A   4      28.977  23.529  28.314  1.00  0.00           C  
ATOM    112  N4   DC A   4      30.013  23.403  29.087  1.00  0.00           N  
ATOM    113  C5   DC A   4      27.933  22.565  28.320  1.00  0.00           C  
ATOM    114  C6   DC A   4      26.845  22.824  27.547  1.00  0.00           C  
ATOM    115  H5'  DC A   4      21.875  24.372  27.363  1.00  0.00           H  
ATOM    116 H5''  DC A   4      21.261  23.666  25.862  1.00  0.00           H  
ATOM    117  H4'  DC A   4      23.178  24.843  25.218  1.00  0.00           H  
ATOM    118  H3'  DC A   4      23.906  21.915  25.521  1.00  0.00           H  
ATOM    119  H2'  DC A   4      26.035  22.410  24.903  1.00  0.00           H  
ATOM    120 H2''  DC A   4      25.551  23.765  23.848  1.00  0.00           H  
ATOM    121  H1'  DC A   4      25.744  25.289  25.502  1.00  0.00           H  
ATOM    122  H41  DC A   4      30.671  24.172  29.063  1.00  0.00           H  
ATOM    123  H42  DC A   4      30.077  22.621  29.704  1.00  0.00           H  
ATOM    124  H5   DC A   4      27.971  21.671  28.922  1.00  0.00           H  
ATOM    125  H6   DC A   4      25.990  22.153  27.536  1.00  0.00           H  
ATOM    126  P    DA A   5      22.605  21.416  23.248  1.00  0.00           P  
ATOM    127  OP1  DA A   5      21.897  21.708  21.983  1.00  0.00           O  
ATOM    128  OP2  DA A   5      21.862  20.857  24.397  1.00  0.00           O  
ATOM    129  O5'  DA A   5      23.835  20.425  22.947  1.00  0.00           O  
ATOM    130  C5'  DA A   5      24.453  20.346  21.669  1.00  0.00           C  
ATOM    131  C4'  DA A   5      25.366  21.545  21.364  1.00  0.00           C  
ATOM    132  O4'  DA A   5      26.609  21.409  22.056  1.00  0.00           O  
ATOM    133  C3'  DA A   5      25.704  21.608  19.868  1.00  0.00           C  
ATOM    134  O3'  DA A   5      25.658  22.968  19.468  1.00  0.00           O  
ATOM    135  C2'  DA A   5      27.112  21.025  19.807  1.00  0.00           C  
ATOM    136  C1'  DA A   5      27.667  21.554  21.120  1.00  0.00           C  
ATOM    137  N9   DA A   5      28.870  20.825  21.580  1.00  0.00           N  
ATOM    138  C8   DA A   5      28.979  19.531  22.029  1.00  0.00           C  
ATOM    139  N7   DA A   5      30.155  19.224  22.513  1.00  0.00           N  
ATOM    140  C5   DA A   5      30.881  20.419  22.358  1.00  0.00           C  
ATOM    141  C6   DA A   5      32.174  20.876  22.717  1.00  0.00           C  
ATOM    142  N6   DA A   5      33.075  20.186  23.389  1.00  0.00           N  
ATOM    143  N1   DA A   5      32.569  22.115  22.432  1.00  0.00           N  
ATOM    144  C2   DA A   5      31.717  22.925  21.820  1.00  0.00           C  
ATOM    145  N3   DA A   5      30.474  22.654  21.452  1.00  0.00           N  
ATOM    146  C4   DA A   5      30.115  21.378  21.752  1.00  0.00           C  
ATOM    147  H5'  DA A   5      23.680  20.271  20.903  1.00  0.00           H  
ATOM    148 H5''  DA A   5      25.054  19.438  21.626  1.00  0.00           H  
ATOM    149  H4'  DA A   5      24.867  22.471  21.652  1.00  0.00           H  
ATOM    150  H3'  DA A   5      25.007  21.015  19.273  1.00  0.00           H  
ATOM    151  H2'  DA A   5      27.067  19.936  19.808  1.00  0.00           H  
ATOM    152 H2''  DA A   5      27.677  21.392  18.950  1.00  0.00           H  
ATOM    153  H1'  DA A   5      27.905  22.617  20.988  1.00  0.00           H  
ATOM    154  H8   DA A   5      28.144  18.842  22.016  1.00  0.00           H  
ATOM    155  H61  DA A   5      33.900  20.678  23.717  1.00  0.00           H  
ATOM    156  H62  DA A   5      32.854  19.255  23.691  1.00  0.00           H  
ATOM    157  H2   DA A   5      32.072  23.926  21.609  1.00  0.00           H  
ATOM    158  P    DT A   6      25.772  23.405  17.934  1.00  0.00           P  
ATOM    159  OP1  DT A   6      25.029  24.670  17.759  1.00  0.00           O  
ATOM    160  OP2  DT A   6      25.414  22.242  17.097  1.00  0.00           O  
ATOM    161  O5'  DT A   6      27.337  23.740  17.752  1.00  0.00           O  
ATOM    162  C5'  DT A   6      27.877  24.926  18.330  1.00  0.00           C  
ATOM    163  C4'  DT A   6      29.374  25.156  18.074  1.00  0.00           C  
ATOM    164  O4'  DT A   6      30.170  24.192  18.733  1.00  0.00           O  
ATOM    165  C3'  DT A   6      29.804  25.135  16.599  1.00  0.00           C  
ATOM    166  O3'  DT A   6      29.992  26.454  16.092  1.00  0.00           O  
ATOM    167  C2'  DT A   6      31.129  24.361  16.625  1.00  0.00           C  
ATOM    168  C1'  DT A   6      31.441  24.194  18.116  1.00  0.00           C  
ATOM    169  N1   DT A   6      32.170  22.938  18.458  1.00  0.00           N  
ATOM    170  C2   DT A   6      33.505  23.030  18.877  1.00  0.00           C  
ATOM    171  O2   DT A   6      34.161  24.067  18.848  1.00  0.00           O  
ATOM    172  N3   DT A   6      34.096  21.869  19.324  1.00  0.00           N  
ATOM    173  C4   DT A   6      33.506  20.627  19.371  1.00  0.00           C  
ATOM    174  O4   DT A   6      34.159  19.675  19.800  1.00  0.00           O  
ATOM    175  C5   DT A   6      32.125  20.589  18.884  1.00  0.00           C  
ATOM    176  C7   DT A   6      31.352  19.280  18.889  1.00  0.00           C  
ATOM    177  C6   DT A   6      31.510  21.724  18.453  1.00  0.00           C  
ATOM    178  H5'  DT A   6      27.718  24.893  19.409  1.00  0.00           H  
ATOM    179 H5''  DT A   6      27.334  25.786  17.939  1.00  0.00           H  
ATOM    180  H4'  DT A   6      29.634  26.134  18.482  1.00  0.00           H  
ATOM    181  H3'  DT A   6      29.070  24.590  16.000  1.00  0.00           H  
ATOM    182 HO3'  DT A   6      29.093  26.851  15.984  1.00  0.00           H  
ATOM    183  H2'  DT A   6      30.990  23.390  16.151  1.00  0.00           H  
ATOM    184 H2''  DT A   6      31.927  24.910  16.123  1.00  0.00           H  
ATOM    185  H1'  DT A   6      32.008  25.064  18.461  1.00  0.00           H  
ATOM    186  H3   DT A   6      35.020  21.955  19.725  1.00  0.00           H  
ATOM    187  H71  DT A   6      31.360  18.861  19.896  1.00  0.00           H  
ATOM    188  H72  DT A   6      30.321  19.429  18.569  1.00  0.00           H  
ATOM    189  H73  DT A   6      31.842  18.569  18.223  1.00  0.00           H  
ATOM    190  H6   DT A   6      30.472  21.707  18.147  1.00  0.00           H  
TER     191       DT A   6                                                      
ATOM    192  O5'  DA B   7      44.246  21.355  23.959  1.00  0.00           O  
ATOM    193  C5'  DA B   7      43.734  22.537  24.565  1.00  0.00           C  
ATOM    194  C4'  DA B   7      43.324  23.585  23.505  1.00  0.00           C  
ATOM    195  O4'  DA B   7      42.422  23.002  22.563  1.00  0.00           O  
ATOM    196  C3'  DA B   7      42.602  24.791  24.130  1.00  0.00           C  
ATOM    197  O3'  DA B   7      42.842  25.978  23.372  1.00  0.00           O  
ATOM    198  C2'  DA B   7      41.150  24.318  24.066  1.00  0.00           C  
ATOM    199  C1'  DA B   7      41.119  23.531  22.755  1.00  0.00           C  
ATOM    200  N9   DA B   7      40.118  22.437  22.759  1.00  0.00           N  
ATOM    201  C8   DA B   7      40.077  21.304  23.537  1.00  0.00           C  
ATOM    202  N7   DA B   7      39.020  20.554  23.347  1.00  0.00           N  
ATOM    203  C5   DA B   7      38.306  21.262  22.361  1.00  0.00           C  
ATOM    204  C6   DA B   7      37.079  21.080  21.672  1.00  0.00           C  
ATOM    205  N6   DA B   7      36.231  20.087  21.859  1.00  0.00           N  
ATOM    206  N1   DA B   7      36.672  21.947  20.744  1.00  0.00           N  
ATOM    207  C2   DA B   7      37.454  22.982  20.473  1.00  0.00           C  
ATOM    208  N3   DA B   7      38.624  23.282  21.019  1.00  0.00           N  
ATOM    209  C4   DA B   7      38.990  22.384  21.974  1.00  0.00           C  
ATOM    210  H5'  DA B   7      44.499  22.974  25.210  1.00  0.00           H  
ATOM    211 H5''  DA B   7      42.871  22.281  25.181  1.00  0.00           H  
ATOM    212  H4'  DA B   7      44.223  23.928  22.992  1.00  0.00           H  
ATOM    213  H3'  DA B   7      42.918  24.941  25.165  1.00  0.00           H  
ATOM    214  H2'  DA B   7      40.936  23.669  24.916  1.00  0.00           H  
ATOM    215 H2''  DA B   7      40.445  25.146  24.047  1.00  0.00           H  
ATOM    216  H1'  DA B   7      40.891  24.230  21.943  1.00  0.00           H  
ATOM    217  H8   DA B   7      40.863  21.055  24.240  1.00  0.00           H  
ATOM    218  H61  DA B   7      35.400  20.061  21.286  1.00  0.00           H  
ATOM    219  H62  DA B   7      36.439  19.371  22.537  1.00  0.00           H  
ATOM    220  H2   DA B   7      37.096  23.663  19.714  1.00  0.00           H  
ATOM    221 HO5'  DA B   7      44.679  20.774  24.622  1.00  0.00           H  
ATOM    222  P    DT B   8      42.384  27.431  23.892  1.00  0.00           P  
ATOM    223  OP1  DT B   8      43.072  28.504  23.143  1.00  0.00           O  
ATOM    224  OP2  DT B   8      42.440  27.472  25.362  1.00  0.00           O  
ATOM    225  O5'  DT B   8      40.849  27.578  23.472  1.00  0.00           O  
ATOM    226  C5'  DT B   8      40.452  27.627  22.105  1.00  0.00           C  
ATOM    227  C4'  DT B   8      38.930  27.530  21.938  1.00  0.00           C  
ATOM    228  O4'  DT B   8      38.461  26.237  22.261  1.00  0.00           O  
ATOM    229  C3'  DT B   8      38.129  28.471  22.841  1.00  0.00           C  
ATOM    230  O3'  DT B   8      37.889  29.720  22.211  1.00  0.00           O  
ATOM    231  C2'  DT B   8      36.832  27.699  23.090  1.00  0.00           C  
ATOM    232  C1'  DT B   8      37.058  26.343  22.411  1.00  0.00           C  
ATOM    233  N1   DT B   8      36.525  25.191  23.187  1.00  0.00           N  
ATOM    234  C2   DT B   8      35.311  24.631  22.777  1.00  0.00           C  
ATOM    235  O2   DT B   8      34.587  25.131  21.923  1.00  0.00           O  
ATOM    236  N3   DT B   8      34.927  23.470  23.399  1.00  0.00           N  
ATOM    237  C4   DT B   8      35.603  22.827  24.405  1.00  0.00           C  
ATOM    238  O4   DT B   8      35.155  21.763  24.825  1.00  0.00           O  
ATOM    239  C5   DT B   8      36.814  23.513  24.858  1.00  0.00           C  
ATOM    240  C7   DT B   8      37.631  22.939  26.003  1.00  0.00           C  
ATOM    241  C6   DT B   8      37.231  24.656  24.248  1.00  0.00           C  
ATOM    242  H5'  DT B   8      40.906  26.795  21.564  1.00  0.00           H  
ATOM    243 H5''  DT B   8      40.797  28.555  21.648  1.00  0.00           H  
ATOM    244  H4'  DT B   8      38.675  27.747  20.899  1.00  0.00           H  
ATOM    245  H3'  DT B   8      38.649  28.594  23.794  1.00  0.00           H  
ATOM    246  H2'  DT B   8      36.687  27.582  24.163  1.00  0.00           H  
ATOM    247 H2''  DT B   8      35.977  28.206  22.642  1.00  0.00           H  
ATOM    248  H1'  DT B   8      36.596  26.361  21.417  1.00  0.00           H  
ATOM    249  H3   DT B   8      34.083  23.032  23.060  1.00  0.00           H  
ATOM    250  H71  DT B   8      37.940  21.924  25.749  1.00  0.00           H  
ATOM    251  H72  DT B   8      38.512  23.548  26.207  1.00  0.00           H  
ATOM    252  H73  DT B   8      37.010  22.893  26.898  1.00  0.00           H  
ATOM    253  H6   DT B   8      38.141  25.147  24.563  1.00  0.00           H  
ATOM    254  P    DG B   9      38.087  31.085  23.023  1.00  0.00           P  
ATOM    255  OP1  DG B   9      37.832  32.234  22.129  1.00  0.00           O  
ATOM    256  OP2  DG B   9      39.384  30.977  23.730  1.00  0.00           O  
ATOM    257  O5'  DG B   9      36.888  31.050  24.081  1.00  0.00           O  
ATOM    258  C5'  DG B   9      35.551  31.302  23.658  1.00  0.00           C  
ATOM    259  C4'  DG B   9      34.599  31.606  24.814  1.00  0.00           C  
ATOM    260  O4'  DG B   9      34.232  30.421  25.495  1.00  0.00           O  
ATOM    261  C3'  DG B   9      35.166  32.568  25.876  1.00  0.00           C  
ATOM    262  O3'  DG B   9      34.360  33.727  26.007  1.00  0.00           O  
ATOM    263  C2'  DG B   9      35.044  31.752  27.162  1.00  0.00           C  
ATOM    264  C1'  DG B   9      33.882  30.836  26.794  1.00  0.00           C  
ATOM    265  N9   DG B   9      33.638  29.670  27.672  1.00  0.00           N  
ATOM    266  C8   DG B   9      34.349  29.187  28.746  1.00  0.00           C  
ATOM    267  N7   DG B   9      33.853  28.095  29.276  1.00  0.00           N  
ATOM    268  C5   DG B   9      32.720  27.844  28.484  1.00  0.00           C  
ATOM    269  C6   DG B   9      31.776  26.760  28.482  1.00  0.00           C  
ATOM    270  O6   DG B   9      31.775  25.750  29.192  1.00  0.00           O  
ATOM    271  N1   DG B   9      30.780  26.894  27.533  1.00  0.00           N  
ATOM    272  C2   DG B   9      30.690  27.946  26.680  1.00  0.00           C  
ATOM    273  N2   DG B   9      29.703  27.962  25.830  1.00  0.00           N  
ATOM    274  N3   DG B   9      31.557  28.946  26.623  1.00  0.00           N  
ATOM    275  C4   DG B   9      32.559  28.834  27.543  1.00  0.00           C  
ATOM    276  H5'  DG B   9      35.175  30.445  23.099  1.00  0.00           H  
ATOM    277 H5''  DG B   9      35.529  32.164  22.997  1.00  0.00           H  
ATOM    278  H4'  DG B   9      33.694  32.055  24.400  1.00  0.00           H  
ATOM    279  H3'  DG B   9      36.209  32.830  25.687  1.00  0.00           H  
ATOM    280  H2'  DG B   9      35.957  31.176  27.316  1.00  0.00           H  
ATOM    281 H2''  DG B   9      34.821  32.384  28.021  1.00  0.00           H  
ATOM    282  H1'  DG B   9      32.962  31.422  26.728  1.00  0.00           H  
ATOM    283  H8   DG B   9      35.254  29.662  29.102  1.00  0.00           H  
ATOM    284  H1   DG B   9      30.089  26.160  27.461  1.00  0.00           H  
ATOM    285  H21  DG B   9      29.006  27.221  25.843  1.00  0.00           H  
ATOM    286  H22  DG B   9      29.617  28.759  25.224  1.00  0.00           H  
ATOM    287  P    DC B  10      34.599  35.017  25.096  1.00  0.00           P  
ATOM    288  OP1  DC B  10      35.231  34.645  23.804  1.00  0.00           O  
ATOM    289  OP2  DC B  10      35.360  35.997  25.887  1.00  0.00           O  
ATOM    290  O5'  DC B  10      33.179  35.685  24.805  1.00  0.00           O  
ATOM    291  C5'  DC B  10      32.198  35.102  23.956  1.00  0.00           C  
ATOM    292  C4'  DC B  10      30.970  34.591  24.728  1.00  0.00           C  
ATOM    293  O4'  DC B  10      31.285  33.476  25.545  1.00  0.00           O  
ATOM    294  C3'  DC B  10      30.328  35.627  25.660  1.00  0.00           C  
ATOM    295  O3'  DC B  10      29.340  36.384  24.976  1.00  0.00           O  
ATOM    296  C2'  DC B  10      29.724  34.753  26.765  1.00  0.00           C  
ATOM    297  C1'  DC B  10      30.230  33.335  26.475  1.00  0.00           C  
ATOM    298  N1   DC B  10      30.719  32.635  27.692  1.00  0.00           N  
ATOM    299  C2   DC B  10      30.019  31.519  28.170  1.00  0.00           C  
ATOM    300  O2   DC B  10      28.976  31.133  27.647  1.00  0.00           O  
ATOM    301  N3   DC B  10      30.464  30.840  29.256  1.00  0.00           N  
ATOM    302  C4   DC B  10      31.541  31.276  29.859  1.00  0.00           C  
ATOM    303  N4   DC B  10      31.939  30.540  30.852  1.00  0.00           N  
ATOM    304  C5   DC B  10      32.282  32.419  29.453  1.00  0.00           C  
ATOM    305  C6   DC B  10      31.840  33.079  28.351  1.00  0.00           C  
ATOM    306  H5'  DC B  10      32.627  34.280  23.381  1.00  0.00           H  
ATOM    307 H5''  DC B  10      31.856  35.866  23.258  1.00  0.00           H  
ATOM    308  H4'  DC B  10      30.214  34.287  24.002  1.00  0.00           H  
ATOM    309  H3'  DC B  10      31.100  36.277  26.075  1.00  0.00           H  
ATOM    310  H2'  DC B  10      30.055  35.120  27.736  1.00  0.00           H  
ATOM    311 H2''  DC B  10      28.635  34.757  26.722  1.00  0.00           H  
ATOM    312  H1'  DC B  10      29.421  32.762  26.008  1.00  0.00           H  
ATOM    313  H41  DC B  10      31.364  29.724  31.019  1.00  0.00           H  
ATOM    314  H42  DC B  10      32.773  30.794  31.337  1.00  0.00           H  
ATOM    315  H5   DC B  10      33.168  32.758  29.964  1.00  0.00           H  
ATOM    316  H6   DC B  10      32.375  33.939  27.953  1.00  0.00           H  
ATOM    317  P    DA B  11      28.641  37.676  25.632  1.00  0.00           P  
ATOM    318  OP1  DA B  11      27.928  38.386  24.548  1.00  0.00           O  
ATOM    319  OP2  DA B  11      29.643  38.398  26.449  1.00  0.00           O  
ATOM    320  O5'  DA B  11      27.539  37.032  26.612  1.00  0.00           O  
ATOM    321  C5'  DA B  11      26.489  37.796  27.186  1.00  0.00           C  
ATOM    322  C4'  DA B  11      25.228  36.920  27.255  1.00  0.00           C  
ATOM    323  O4'  DA B  11      25.405  35.814  28.147  1.00  0.00           O  
ATOM    324  C3'  DA B  11      23.975  37.660  27.750  1.00  0.00           C  
ATOM    325  O3'  DA B  11      22.839  37.033  27.159  1.00  0.00           O  
ATOM    326  C2'  DA B  11      24.085  37.433  29.256  1.00  0.00           C  
ATOM    327  C1'  DA B  11      24.598  35.993  29.306  1.00  0.00           C  
ATOM    328  N9   DA B  11      25.359  35.681  30.539  1.00  0.00           N  
ATOM    329  C8   DA B  11      26.326  36.431  31.169  1.00  0.00           C  
ATOM    330  N7   DA B  11      26.771  35.914  32.282  1.00  0.00           N  
ATOM    331  C5   DA B  11      26.037  34.724  32.393  1.00  0.00           C  
ATOM    332  C6   DA B  11      26.000  33.660  33.325  1.00  0.00           C  
ATOM    333  N6   DA B  11      26.738  33.591  34.415  1.00  0.00           N  
ATOM    334  N1   DA B  11      25.186  32.622  33.150  1.00  0.00           N  
ATOM    335  C2   DA B  11      24.423  32.601  32.066  1.00  0.00           C  
ATOM    336  N3   DA B  11      24.353  33.508  31.096  1.00  0.00           N  
ATOM    337  C4   DA B  11      25.188  34.563  31.329  1.00  0.00           C  
ATOM    338  H5'  DA B  11      26.279  38.663  26.557  1.00  0.00           H  
ATOM    339 H5''  DA B  11      26.781  38.137  28.179  1.00  0.00           H  
ATOM    340  H4'  DA B  11      25.052  36.556  26.243  1.00  0.00           H  
ATOM    341  H3'  DA B  11      24.004  38.724  27.501  1.00  0.00           H  
ATOM    342  H2'  DA B  11      24.809  38.132  29.674  1.00  0.00           H  
ATOM    343 H2''  DA B  11      23.133  37.543  29.772  1.00  0.00           H  
ATOM    344  H1'  DA B  11      23.734  35.323  29.249  1.00  0.00           H  
ATOM    345  H8   DA B  11      26.693  37.368  30.772  1.00  0.00           H  
ATOM    346  H61  DA B  11      26.691  32.760  34.996  1.00  0.00           H  
ATOM    347  H62  DA B  11      27.326  34.371  34.646  1.00  0.00           H  
ATOM    348  H2   DA B  11      23.782  31.736  31.956  1.00  0.00           H  
ATOM    349  P    DT B  12      21.328  37.469  27.462  1.00  0.00           P  
ATOM    350  OP1  DT B  12      20.554  36.873  26.350  1.00  0.00           O  
ATOM    351  OP2  DT B  12      21.283  38.917  27.715  1.00  0.00           O  
ATOM    352  O5'  DT B  12      20.968  36.681  28.798  1.00  0.00           O  
ATOM    353  C5'  DT B  12      20.728  35.280  28.794  1.00  0.00           C  
ATOM    354  C4'  DT B  12      20.405  34.758  30.199  1.00  0.00           C  
ATOM    355  O4'  DT B  12      21.550  34.791  31.035  1.00  0.00           O  
ATOM    356  C3'  DT B  12      19.314  35.573  30.919  1.00  0.00           C  
ATOM    357  O3'  DT B  12      18.107  34.838  31.062  1.00  0.00           O  
ATOM    358  C2'  DT B  12      19.945  35.877  32.277  1.00  0.00           C  
ATOM    359  C1'  DT B  12      21.061  34.837  32.360  1.00  0.00           C  
ATOM    360  N1   DT B  12      22.136  35.159  33.342  1.00  0.00           N  
ATOM    361  C2   DT B  12      22.421  34.214  34.337  1.00  0.00           C  
ATOM    362  O2   DT B  12      21.887  33.111  34.408  1.00  0.00           O  
ATOM    363  N3   DT B  12      23.372  34.553  35.265  1.00  0.00           N  
ATOM    364  C4   DT B  12      24.096  35.719  35.293  1.00  0.00           C  
ATOM    365  O4   DT B  12      24.943  35.856  36.173  1.00  0.00           O  
ATOM    366  C5   DT B  12      23.766  36.665  34.224  1.00  0.00           C  
ATOM    367  C7   DT B  12      24.489  37.998  34.137  1.00  0.00           C  
ATOM    368  C6   DT B  12      22.817  36.360  33.296  1.00  0.00           C  
ATOM    369  H5'  DT B  12      21.606  34.754  28.417  1.00  0.00           H  
ATOM    370 H5''  DT B  12      19.884  35.057  28.140  1.00  0.00           H  
ATOM    371  H4'  DT B  12      20.068  33.722  30.119  1.00  0.00           H  
ATOM    372  H3'  DT B  12      19.115  36.506  30.393  1.00  0.00           H  
ATOM    373 HO3'  DT B  12      17.664  34.851  30.186  1.00  0.00           H  
ATOM    374  H2'  DT B  12      20.345  36.889  32.264  1.00  0.00           H  
ATOM    375 H2''  DT B  12      19.242  35.766  33.097  1.00  0.00           H  
ATOM    376  H1'  DT B  12      20.604  33.873  32.608  1.00  0.00           H  
ATOM    377  H3   DT B  12      23.577  33.867  35.978  1.00  0.00           H  
ATOM    378  H71  DT B  12      25.562  37.820  34.066  1.00  0.00           H  
ATOM    379  H72  DT B  12      24.158  38.574  33.273  1.00  0.00           H  
ATOM    380  H73  DT B  12      24.297  38.569  35.046  1.00  0.00           H  
ATOM    381  H6   DT B  12      22.591  37.059  32.503  1.00  0.00           H  
TER     382       DT B  12                                                      
HETATM  383  C1  XR2 A  13      27.774  28.255  33.690  1.00  0.00           C  
HETATM  384  C2  XR2 A  13      26.717  27.342  33.597  1.00  0.00           C  
HETATM  385  C3  XR2 A  13      25.672  27.546  32.708  1.00  0.00           C  
HETATM  386  C4  XR2 A  13      25.691  28.645  31.860  1.00  0.00           C  
HETATM  387  C12 XR2 A  13      26.720  29.576  31.929  1.00  0.00           C  
HETATM  388  C11 XR2 A  13      27.758  29.416  32.885  1.00  0.00           C  
HETATM  389  N5  XR2 A  13      26.696  30.605  31.048  1.00  0.00           N  
HETATM  390  N10 XR2 A  13      28.732  30.364  32.990  1.00  0.00           N  
HETATM  391  C13 XR2 A  13      27.664  31.540  31.172  1.00  0.00           C  
HETATM  392  C14 XR2 A  13      28.659  31.450  32.172  1.00  0.00           C  
HETATM  393  C6  XR2 A  13      27.648  32.634  30.311  1.00  0.00           C  
HETATM  394  C7  XR2 A  13      28.571  33.666  30.453  1.00  0.00           C  
HETATM  395  C8  XR2 A  13      29.518  33.609  31.472  1.00  0.00           C  
HETATM  396  C9  XR2 A  13      29.572  32.505  32.328  1.00  0.00           C  
HETATM  397  C9A XR2 A  13      30.591  32.495  33.462  1.00  0.00           C  
HETATM  398  C   XR2 A  13      28.891  27.870  34.618  1.00  0.00           C  
HETATM  399  O   XR2 A  13      28.928  26.810  35.205  1.00  0.00           O  
HETATM  400  N   XR2 A  13      29.932  28.694  34.762  1.00  0.00           N  
HETATM  401  CA  XR2 A  13      31.138  28.388  35.542  1.00  0.00           C  
HETATM  402  CB  XR2 A  13      32.084  27.470  34.735  1.00  0.00           C  
HETATM  403  NG  XR2 A  13      32.325  27.963  33.314  1.00  0.00           N  
HETATM  404  CD  XR2 A  13      33.351  27.178  32.507  1.00  0.00           C  
HETATM  405  N'  XR2 A  13      34.167  23.559  28.528  1.00  0.00           N  
HETATM  406  C'  XR2 A  13      34.683  24.647  27.944  1.00  0.00           C  
HETATM  407  O'  XR2 A  13      35.582  25.216  28.531  1.00  0.00           O  
HETATM  408  C1' XR2 A  13      34.060  25.179  26.679  1.00  0.00           C  
HETATM  409  C2' XR2 A  13      34.582  26.375  26.177  1.00  0.00           C  
HETATM  410  C3' XR2 A  13      33.981  27.026  25.104  1.00  0.00           C  
HETATM  411  C4' XR2 A  13      32.837  26.498  24.528  1.00  0.00           C  
HETATM  412  CCX XR2 A  13      32.297  25.301  24.990  1.00  0.00           C  
HETATM  413  N5' XR2 A  13      31.141  24.870  24.428  1.00  0.00           N  
HETATM  414  CDX XR2 A  13      30.648  23.689  24.871  1.00  0.00           C  
HETATM  415  CEX XR2 A  13      31.334  22.918  25.840  1.00  0.00           C  
HETATM  416  NAX XR2 A  13      32.452  23.396  26.444  1.00  0.00           N  
HETATM  417  CBX XR2 A  13      32.938  24.601  26.042  1.00  0.00           C  
HETATM  418  C9' XR2 A  13      30.846  21.650  26.183  1.00  0.00           C  
HETATM  419  C8' XR2 A  13      29.657  21.182  25.616  1.00  0.00           C  
HETATM  420  C7' XR2 A  13      28.951  21.971  24.719  1.00  0.00           C  
HETATM  421  C6' XR2 A  13      29.452  23.219  24.346  1.00  0.00           C  
HETATM  422  C9X XR2 A  13      31.613  20.749  27.144  1.00  0.00           C  
HETATM  423  CA' XR2 A  13      34.564  22.998  29.828  1.00  0.00           C  
HETATM  424  CB' XR2 A  13      33.743  23.598  30.993  1.00  0.00           C  
HETATM  425  NG' XR2 A  13      33.794  25.115  31.053  1.00  0.00           N  
HETATM  426  CD' XR2 A  13      32.982  25.708  32.194  1.00  0.00           C  
HETATM  427  H2  XR2 A  13      26.714  26.444  34.217  1.00  0.00           H  
HETATM  428  H3  XR2 A  13      24.854  26.832  32.654  1.00  0.00           H  
HETATM  429  H4  XR2 A  13      24.896  28.786  31.131  1.00  0.00           H  
HETATM  430  H6  XR2 A  13      26.883  32.684  29.540  1.00  0.00           H  
HETATM  431  H7  XR2 A  13      28.526  34.534  29.795  1.00  0.00           H  
HETATM  432  H8  XR2 A  13      30.210  34.440  31.603  1.00  0.00           H  
HETATM  433  H91 XR2 A  13      30.075  32.510  34.426  1.00  0.00           H  
HETATM  434  H92 XR2 A  13      31.249  33.366  33.417  1.00  0.00           H  
HETATM  435  H93 XR2 A  13      31.211  31.599  33.419  1.00  0.00           H  
HETATM  436  HN  XR2 A  13      29.790  29.603  34.330  1.00  0.00           H  
HETATM  437  HA1 XR2 A  13      30.852  27.887  36.473  1.00  0.00           H  
HETATM  438  HA2 XR2 A  13      31.646  29.321  35.805  1.00  0.00           H  
HETATM  439  HB1 XR2 A  13      31.622  26.478  34.670  1.00  0.00           H  
HETATM  440  HB2 XR2 A  13      33.044  27.378  35.255  1.00  0.00           H  
HETATM  441  HG1 XR2 A  13      32.585  28.966  33.338  1.00  0.00           H  
HETATM  442  HG2 XR2 A  13      31.405  27.960  32.786  1.00  0.00           H  
HETATM  443  HD1 XR2 A  13      33.463  27.709  31.555  1.00  0.00           H  
HETATM  444  HD2 XR2 A  13      34.314  27.224  33.030  1.00  0.00           H  
HETATM  445  HN' XR2 A  13      33.439  23.110  27.980  1.00  0.00           H  
HETATM  446  H2' XR2 A  13      35.447  26.839  26.653  1.00  0.00           H  
HETATM  447  H3' XR2 A  13      34.376  27.977  24.749  1.00  0.00           H  
HETATM  448  H4' XR2 A  13      32.338  27.022  23.717  1.00  0.00           H  
HETATM  449  H8' XR2 A  13      29.284  20.190  25.869  1.00  0.00           H  
HETATM  450  H7' XR2 A  13      28.036  21.594  24.268  1.00  0.00           H  
HETATM  451  H6' XR2 A  13      28.931  23.821  23.605  1.00  0.00           H  
HETATM  452 H91' XR2 A  13      31.608  21.169  28.151  1.00  0.00           H  
HETATM  453 H92' XR2 A  13      31.179  19.748  27.188  1.00  0.00           H  
HETATM  454 H93' XR2 A  13      32.652  20.647  26.817  1.00  0.00           H  
HETATM  455 HA1' XR2 A  13      35.632  23.179  29.997  1.00  0.00           H  
HETATM  456 HA2' XR2 A  13      34.412  21.914  29.806  1.00  0.00           H  
HETATM  457 HB1' XR2 A  13      32.694  23.307  30.885  1.00  0.00           H  
HETATM  458 HB2' XR2 A  13      34.121  23.201  31.942  1.00  0.00           H  
HETATM  459 HG1' XR2 A  13      34.801  25.428  31.049  1.00  0.00           H  
HETATM  460 HG2' XR2 A  13      33.423  25.487  30.139  1.00  0.00           H  
HETATM  461 HD1' XR2 A  13      31.923  25.643  31.904  1.00  0.00           H  
HETATM  462 HD2' XR2 A  13      33.134  25.090  33.085  1.00  0.00           H  
CONECT  383  384  388  398                                                      
CONECT  384  383  385  427                                                      
CONECT  385  384  386  428                                                      
CONECT  386  385  387  429                                                      
CONECT  387  386  388  389                                                      
CONECT  388  383  387  390                                                      
CONECT  389  387  391                                                           
CONECT  390  388  392                                                           
CONECT  391  389  392  393                                                      
CONECT  392  390  391  396                                                      
CONECT  393  391  394  430                                                      
CONECT  394  393  395  431                                                      
CONECT  395  394  396  432                                                      
CONECT  396  392  395  397                                                      
CONECT  397  396  433  434  435                                                 
CONECT  398  383  399  400                                                      
CONECT  399  398                                                                
CONECT  400  398  401  436                                                      
CONECT  401  400  402  437  438                                                 
CONECT  402  401  403  439  440                                                 
CONECT  403  402  404  441  442                                                 
CONECT  404  403  426  443  444                                                 
CONECT  405  406  423  445                                                      
CONECT  406  405  407  408                                                      
CONECT  407  406                                                                
CONECT  408  406  409  417                                                      
CONECT  409  408  410  446                                                      
CONECT  410  409  411  447                                                      
CONECT  411  410  412  448                                                      
CONECT  412  411  413  417                                                      
CONECT  413  412  414                                                           
CONECT  414  413  415  421                                                      
CONECT  415  414  416  418                                                      
CONECT  416  415  417                                                           
CONECT  417  408  412  416                                                      
CONECT  418  415  419  422                                                      
CONECT  419  418  420  449                                                      
CONECT  420  419  421  450                                                      
CONECT  421  414  420  451                                                      
CONECT  422  418  452  453  454                                                 
CONECT  423  405  424  455  456                                                 
CONECT  424  423  425  457  458                                                 
CONECT  425  424  426  459  460                                                 
CONECT  426  404  425  461  462                                                 
CONECT  427  384                                                                
CONECT  428  385                                                                
CONECT  429  386                                                                
CONECT  430  393                                                                
CONECT  431  394                                                                
CONECT  432  395                                                                
CONECT  433  397                                                                
CONECT  434  397                                                                
CONECT  435  397                                                                
CONECT  436  400                                                                
CONECT  437  401                                                                
CONECT  438  401                                                                
CONECT  439  402                                                                
CONECT  440  402                                                                
CONECT  441  403                                                                
CONECT  442  403                                                                
CONECT  443  404                                                                
CONECT  444  404                                                                
CONECT  445  405                                                                
CONECT  446  409                                                                
CONECT  447  410                                                                
CONECT  448  411                                                                
CONECT  449  419                                                                
CONECT  450  420                                                                
CONECT  451  421                                                                
CONECT  452  422                                                                
CONECT  453  422                                                                
CONECT  454  422                                                                
CONECT  455  423                                                                
CONECT  456  423                                                                
CONECT  457  424                                                                
CONECT  458  424                                                                
CONECT  459  425                                                                
CONECT  460  425                                                                
CONECT  461  426                                                                
CONECT  462  426                                                                
MASTER      138    0    1    0    0    0    2    6  460    2   80    2          
END