HEADER    HYDROLASE INHIBITOR, TOXIN              14-FEB-96   1EVD              
TITLE     NMR STRUCTURE OF CYANOBACTERIAL TOXIN, PHOSPHATASE-1/-2A INHIBITOR    
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: MOTUPORIN;                                                 
COMPND   3 CHAIN: A;                                                            
COMPND   4 SYNONYM: NODULARIN-V                                                 
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: UNIDENTIFIED;                                   
SOURCE   3 ORGANISM_TAXID: 32644;                                               
SOURCE   4 OTHER_DETAILS: ISOLATED FROM MARINE SPONGE                           
KEYWDS    CYANOBACTERIAL TOXIN, PHOSPHATASE-1/-2A INHIBITOR, HYDROLASE          
KEYWDS   2 INHIBITOR, TOXIN                                                     
EXPDTA    SOLUTION NMR                                                          
AUTHOR    J.R.BAGU,B.D.SYKES                                                    
REVDAT   4   15-NOV-23 1EVD    1       LINK   ATOM                              
REVDAT   3   13-JUL-11 1EVD    1       VERSN                                    
REVDAT   2   24-FEB-09 1EVD    1       VERSN                                    
REVDAT   1   08-NOV-96 1EVD    0                                                
JRNL        AUTH   J.R.BAGU,F.D.SONNICHSEN,D.WILLIAMS,R.J.ANDERSEN,B.D.SYKES,   
JRNL        AUTH 2 C.F.HOLMES                                                   
JRNL        TITL   COMPARISON OF THE SOLUTION STRUCTURES OF MICROCYSTIN-LR AND  
JRNL        TITL 2 MOTUPORIN.                                                   
JRNL        REF    NAT.STRUCT.BIOL.              V.   2   114 1995              
JRNL        REFN                   ISSN 1072-8368                               
JRNL        PMID   7749913                                                      
JRNL        DOI    10.1038/NSB0295-114                                          
REMARK   1                                                                      
REMARK   1 REFERENCE 1                                                          
REMARK   1  AUTH   C.F.B.HOLMES,M.P.BOLAND                                      
REMARK   1  TITL   INHIBITORS OF PROTEIN PHOSPHATASE-1 AND-2A; TWO OF MAJOR     
REMARK   1  TITL 2 SERINE/THREONINE PROTEIN PHOSPHATASES INVOLVED IN CELLULAR   
REMARK   1  TITL 3 REGULATION                                                   
REMARK   1  REF    CURR.OPIN.STRUCT.BIOL.        V.   3   934 1993              
REMARK   1  REFN                   ISSN 0959-440X                               
REMARK   2                                                                      
REMARK   2 RESOLUTION. NOT APPLICABLE.                                          
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : DGII                                                 
REMARK   3   AUTHORS     : HAVEL                                                
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 1EVD COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY BNL.                                
REMARK 100 THE DEPOSITION ID IS D_1000173182.                                   
REMARK 210                                                                      
REMARK 210 EXPERIMENTAL DETAILS                                                 
REMARK 210  EXPERIMENT TYPE                : NMR                                
REMARK 210  TEMPERATURE           (KELVIN) : 278                                
REMARK 210  PH                             : 7                                  
REMARK 210  IONIC STRENGTH                 : NULL                               
REMARK 210  PRESSURE                       : NULL                               
REMARK 210  SAMPLE CONTENTS                : NULL                               
REMARK 210                                                                      
REMARK 210  NMR EXPERIMENTS CONDUCTED      : NULL                               
REMARK 210  SPECTROMETER FIELD STRENGTH    : NULL                               
REMARK 210  SPECTROMETER MODEL             : NULL                               
REMARK 210  SPECTROMETER MANUFACTURER      : NULL                               
REMARK 210                                                                      
REMARK 210  STRUCTURE DETERMINATION.                                            
REMARK 210   SOFTWARE USED                 : NULL                               
REMARK 210   METHOD USED                   : NULL                               
REMARK 210                                                                      
REMARK 210 CONFORMERS, NUMBER CALCULATED   : NULL                               
REMARK 210 CONFORMERS, NUMBER SUBMITTED    : 1                                  
REMARK 210 CONFORMERS, SELECTION CRITERIA  : NULL                               
REMARK 210                                                                      
REMARK 210 BEST REPRESENTATIVE CONFORMER IN THIS ENSEMBLE : NULL                
REMARK 210                                                                      
REMARK 210 REMARK: NULL                                                         
REMARK 215                                                                      
REMARK 215 NMR STUDY                                                            
REMARK 215 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM SOLUTION           
REMARK 215 NMR DATA.  PROTEIN DATA BANK CONVENTIONS REQUIRE THAT                
REMARK 215 CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES ON              
REMARK 215 THESE RECORDS ARE MEANINGLESS.                                       
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 400                                                                      
REMARK 400 COMPOUND                                                             
REMARK 400                                                                      
REMARK 400 THE MOTUPORIN IS CYCLIC PEPTIDE, A MEMBER OF TOXIN CLASS.            
REMARK 400                                                                      
REMARK 400  GROUP: 1                                                            
REMARK 400   NAME: MOTUPORIN                                                    
REMARK 400   CHAIN: A                                                           
REMARK 400   COMPONENT_1: PEPTIDE LIKE POLYMER                                  
REMARK 400   DESCRIPTION: NULL                                                  
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (RES=RESIDUE NAME;         
REMARK 470 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):         
REMARK 470     RES CSSEQI  ATOMS                                                
REMARK 470     ACB A   1    OD1                                                 
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS                                             
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   CG   ACB A     1     N    VAL A     2              1.32            
REMARK 500   N    ACB A     1     C    MDH A     5              1.32            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    VAL A   2   CG1 -  CB  -  CG2 ANGL. DEV. =  -9.7 DEGREES          
REMARK 500    VAL A   2   CA  -  CB  -  CG2 ANGL. DEV. =   9.4 DEGREES          
REMARK 500    1ZN A   3   CA  -  C   -  N   ANGL. DEV. =  21.8 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY                                       
REMARK 500                                                                      
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY                       
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER                 
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;                     
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;                            
REMARK 500 I=INSERTION CODE).                                                   
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        ANGLE                                           
REMARK 500    1ZN A   3        -13.40                                           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 1EVC   RELATED DB: PDB                                   
DBREF  1EVD A    1     5  NOR    NOR00825 NOR00825         1      5             
SEQRES   1 A    5  ACB VAL 1ZN FGA MDH                                          
HET    ACB  A   1      15                                                       
HET    1ZN  A   3      50                                                       
HET    FGA  A   4      14                                                       
HET    MDH  A   5      14                                                       
HETNAM     ACB 3-METHYL-BETA-D-ASPARTIC ACID                                    
HETNAM     1ZN (2S,3S,4E,6E,8S,9S)-3-AMINO-9-METHOXY-2,6,8-TRIMETHYL-           
HETNAM   2 1ZN  10-PHENYLDECA-4,6-DIENOIC ACID                                  
HETNAM     FGA GAMMA-D-GLUTAMIC ACID                                            
HETNAM     MDH N-METHYLDEHYDROBUTYRINE                                          
HETSYN     ACB (3S)-3-METHYL-D-ASPARTIC ACID; D-METHYL ASPARTIC ACID            
HETSYN     FGA D-GLUTAMIC ACID                                                  
FORMUL   1  ACB    C5 H9 N O4                                                   
FORMUL   1  1ZN    C20 H29 N O3                                                 
FORMUL   1  FGA    C5 H9 N O4                                                   
FORMUL   1  MDH    C5 H9 N O2                                                   
LINK         C   ACB A   1                 N   VAL A   2     1555   1555  3.96  
LINK         C   VAL A   2                 N   1ZN A   3     1555   1555  1.30  
LINK         C   1ZN A   3                 N   FGA A   4     1555   1555  1.30  
LINK         CD  FGA A   4                 N   MDH A   5     1555   1555  1.32  
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
HETATM    1  C   ACB A   1       2.446   1.907  -2.265  1.00  0.00           C  
HETATM    2  O   ACB A   1       1.420   2.124  -1.611  1.00  0.00           O  
HETATM    3  OXT ACB A   1       2.511   0.914  -3.003  1.00  0.00           O  
HETATM    4  CA  ACB A   1       3.666   2.852  -2.160  1.00  0.00           C  
HETATM    5  N   ACB A   1       4.493   2.334  -1.074  1.00  0.00           N  
HETATM    6  CB  ACB A   1       3.309   4.300  -1.999  1.00  0.00           C  
HETATM    7  CG  ACB A   1       2.709   4.844  -0.712  1.00  0.00           C  
HETATM    8  C4  ACB A   1       4.466   5.181  -2.274  1.00  0.00           C  
HETATM    9  OD2 ACB A   1       3.383   4.704   0.319  1.00  0.00           O  
HETATM   10  HA  ACB A   1       4.178   2.737  -3.108  1.00  0.00           H  
HETATM   11  H   ACB A   1       4.212   2.446  -0.037  1.00  0.00           H  
HETATM   12  HB3 ACB A   1       2.571   4.520  -2.743  1.00  0.00           H  
HETATM   13  H41 ACB A   1       4.853   5.028  -3.270  1.00  0.00           H  
HETATM   14  H42 ACB A   1       4.192   6.216  -2.186  1.00  0.00           H  
HETATM   15  H43 ACB A   1       5.274   5.007  -1.597  1.00  0.00           H  
ATOM     16  N   VAL A   2       1.508   5.383  -0.621  1.00  0.00           N  
ATOM     17  CA  VAL A   2       0.831   5.820   0.601  1.00  0.00           C  
ATOM     18  C   VAL A   2      -0.168   4.765   1.046  1.00  0.00           C  
ATOM     19  O   VAL A   2      -1.267   5.122   1.495  1.00  0.00           O  
ATOM     20  CB  VAL A   2       0.462   7.363   0.614  1.00  0.00           C  
ATOM     21  CG1 VAL A   2       0.534   8.119  -0.686  1.00  0.00           C  
ATOM     22  CG2 VAL A   2      -0.874   7.823   1.149  1.00  0.00           C  
ATOM     23  H   VAL A   2       1.059   5.482  -1.599  1.00  0.00           H  
ATOM     24  HA  VAL A   2       1.548   5.833   1.415  1.00  0.00           H  
ATOM     25  HB  VAL A   2       1.187   7.863   1.260  1.00  0.00           H  
ATOM     26 HG11 VAL A   2       1.546   8.018  -1.066  1.00  0.00           H  
ATOM     27 HG12 VAL A   2      -0.168   7.661  -1.388  1.00  0.00           H  
ATOM     28 HG13 VAL A   2       0.296   9.193  -0.577  1.00  0.00           H  
ATOM     29 HG21 VAL A   2      -0.984   7.458   2.165  1.00  0.00           H  
ATOM     30 HG22 VAL A   2      -0.998   8.921   1.154  1.00  0.00           H  
ATOM     31 HG23 VAL A   2      -1.665   7.396   0.524  1.00  0.00           H  
HETATM   32  C1  1ZN A   3      -7.398  -0.933  -3.062  1.00  0.00           C  
HETATM   33  O1  1ZN A   3      -6.743  -0.971  -1.826  1.00  0.00           O  
HETATM   34  C2  1ZN A   3      -5.407  -1.333  -1.916  1.00  0.00           C  
HETATM   35  C3  1ZN A   3      -5.116  -2.581  -2.743  1.00  0.00           C  
HETATM   36  C4  1ZN A   3      -6.159  -3.648  -3.029  1.00  0.00           C  
HETATM   37  C5  1ZN A   3      -7.053  -4.123  -2.061  1.00  0.00           C  
HETATM   38  C6  1ZN A   3      -8.144  -4.905  -2.440  1.00  0.00           C  
HETATM   39  C7  1ZN A   3      -8.327  -5.247  -3.779  1.00  0.00           C  
HETATM   40  C8  1ZN A   3      -7.409  -4.834  -4.738  1.00  0.00           C  
HETATM   41  C9  1ZN A   3      -6.323  -4.053  -4.364  1.00  0.00           C  
HETATM   42  C10 1ZN A   3      -4.576  -0.178  -2.405  1.00  0.00           C  
HETATM   43  C11 1ZN A   3      -5.053   0.691  -3.523  1.00  0.00           C  
HETATM   44  C12 1ZN A   3      -4.103   0.686  -1.290  1.00  0.00           C  
HETATM   45  C13 1ZN A   3      -2.835   1.056  -1.225  1.00  0.00           C  
HETATM   46  C14 1ZN A   3      -1.920   0.679  -2.352  1.00  0.00           C  
HETATM   47  C15 1ZN A   3      -2.429   1.676  -0.130  1.00  0.00           C  
HETATM   48  C16 1ZN A   3      -1.153   1.597   0.239  1.00  0.00           C  
HETATM   49  CA  1ZN A   3      -0.669   2.408   1.336  1.00  0.00           C  
HETATM   50  N   1ZN A   3       0.187   3.520   0.932  1.00  0.00           N  
HETATM   51  C18 1ZN A   3       0.018   1.612   2.437  1.00  0.00           C  
HETATM   52  C19 1ZN A   3      -0.875   0.772   3.283  1.00  0.00           C  
HETATM   53  C   1ZN A   3       0.830   2.579   3.261  1.00  0.00           C  
HETATM   54  O   1ZN A   3       0.489   3.730   3.569  1.00  0.00           O  
HETATM   55  H1  1ZN A   3      -7.646   0.078  -3.283  1.00  0.00           H  
HETATM   56  H29 1ZN A   3      -8.180  -1.648  -3.035  1.00  0.00           H  
HETATM   57  H3  1ZN A   3      -6.783  -1.261  -3.906  1.00  0.00           H  
HETATM   58  H4  1ZN A   3      -5.093  -1.571  -0.918  1.00  0.00           H  
HETATM   59  H5  1ZN A   3      -4.827  -2.168  -3.708  1.00  0.00           H  
HETATM   60  H6  1ZN A   3      -4.211  -2.970  -2.344  1.00  0.00           H  
HETATM   61  H7  1ZN A   3      -6.955  -3.819  -1.029  1.00  0.00           H  
HETATM   62  H8  1ZN A   3      -8.871  -5.213  -1.704  1.00  0.00           H  
HETATM   63  H9  1ZN A   3      -9.195  -5.814  -4.083  1.00  0.00           H  
HETATM   64  H10 1ZN A   3      -7.553  -5.085  -5.779  1.00  0.00           H  
HETATM   65  H11 1ZN A   3      -5.648  -3.706  -5.135  1.00  0.00           H  
HETATM   66  H12 1ZN A   3      -3.747  -0.687  -2.889  1.00  0.00           H  
HETATM   67  H13 1ZN A   3      -5.339   0.073  -4.387  1.00  0.00           H  
HETATM   68  H14 1ZN A   3      -4.279   1.378  -3.831  1.00  0.00           H  
HETATM   69  H15 1ZN A   3      -5.888   1.275  -3.149  1.00  0.00           H  
HETATM   70  H16 1ZN A   3      -4.807   0.964  -0.524  1.00  0.00           H  
HETATM   71  H17 1ZN A   3      -1.707  -0.386  -2.240  1.00  0.00           H  
HETATM   72  H18 1ZN A   3      -2.399   0.807  -3.326  1.00  0.00           H  
HETATM   73  H19 1ZN A   3      -1.038   1.297  -2.345  1.00  0.00           H  
HETATM   74  H20 1ZN A   3      -3.139   2.230   0.495  1.00  0.00           H  
HETATM   75  H21 1ZN A   3      -0.425   0.946  -0.249  1.00  0.00           H  
HETATM   76  HA  1ZN A   3      -1.517   2.888   1.818  1.00  0.00           H  
HETATM   77  H   1ZN A   3       1.183   3.351   0.549  1.00  0.00           H  
HETATM   78  H25 1ZN A   3       0.663   0.893   1.940  1.00  0.00           H  
HETATM   79  H26 1ZN A   3      -0.307   0.152   3.957  1.00  0.00           H  
HETATM   80  H27 1ZN A   3      -1.473   0.122   2.668  1.00  0.00           H  
HETATM   81  H28 1ZN A   3      -1.548   1.362   3.891  1.00  0.00           H  
HETATM   82  N   FGA A   4       1.905   2.010   3.721  1.00  0.00           N  
HETATM   83  CA  FGA A   4       2.861   2.665   4.609  1.00  0.00           C  
HETATM   84  C   FGA A   4       2.978   1.832   5.914  1.00  0.00           C  
HETATM   85  O   FGA A   4       4.055   1.309   6.252  1.00  0.00           O  
HETATM   86  CB  FGA A   4       4.163   2.893   3.900  1.00  0.00           C  
HETATM   87  CG  FGA A   4       4.920   1.738   3.242  1.00  0.00           C  
HETATM   88  CD  FGA A   4       5.387   1.427   1.819  1.00  0.00           C  
HETATM   89  OE1 FGA A   4       4.268   1.471   1.286  1.00  0.00           O  
HETATM   90  H   FGA A   4       2.037   0.986   3.403  1.00  0.00           H  
HETATM   91  HA  FGA A   4       2.509   3.633   4.934  1.00  0.00           H  
HETATM   92  HB2 FGA A   4       3.991   3.811   3.314  1.00  0.00           H  
HETATM   93  HB3 FGA A   4       4.800   3.383   4.675  1.00  0.00           H  
HETATM   94  HG2 FGA A   4       5.896   1.596   3.724  1.00  0.00           H  
HETATM   95  HG3 FGA A   4       4.649   0.702   3.511  1.00  0.00           H  
HETATM   96  N   MDH A   5       6.206   1.058   0.852  1.00  0.00           N  
HETATM   97  CM  MDH A   5       7.489   1.578   1.487  1.00  0.00           C  
HETATM   98  CA  MDH A   5       6.631   0.777  -0.516  1.00  0.00           C  
HETATM   99  C   MDH A   5       5.615   1.660  -1.243  1.00  0.00           C  
HETATM  100  O   MDH A   5       6.060   1.412  -2.374  1.00  0.00           O  
HETATM  101  CB  MDH A   5       7.635  -0.135  -0.796  1.00  0.00           C  
HETATM  102  CG  MDH A   5       8.551  -0.894   0.158  1.00  0.00           C  
HETATM  103  HM1 MDH A   5       7.445   2.578   1.947  1.00  0.00           H  
HETATM  104  HM2 MDH A   5       7.772   0.868   2.288  1.00  0.00           H  
HETATM  105  HM3 MDH A   5       8.357   1.696   0.831  1.00  0.00           H  
HETATM  106  HB  MDH A   5       7.889  -0.359  -1.828  1.00  0.00           H  
HETATM  107  HG1 MDH A   5       9.111  -0.247   0.854  1.00  0.00           H  
HETATM  108  HG2 MDH A   5       9.345  -1.418  -0.380  1.00  0.00           H  
HETATM  109  HG3 MDH A   5       7.988  -1.593   0.793  1.00  0.00           H  
TER     110      MDH A   5                                                      
CONECT    1    2    3    4   16                                                 
CONECT    2    1                                                                
CONECT    3    1                                                                
CONECT    4    1    5    6   10                                                 
CONECT    5    4   11                                                           
CONECT    6    4    7    8   12                                                 
CONECT    7    6    9                                                           
CONECT    8    6   13   14   15                                                 
CONECT    9    7                                                                
CONECT   10    4                                                                
CONECT   11    5                                                                
CONECT   12    6                                                                
CONECT   13    8                                                                
CONECT   14    8                                                                
CONECT   15    8                                                                
CONECT   16    1                                                                
CONECT   18   50                                                                
CONECT   32   33   55   56   57                                                 
CONECT   33   32   34                                                           
CONECT   34   33   35   42   58                                                 
CONECT   35   34   36   59   60                                                 
CONECT   36   35   37   41                                                      
CONECT   37   36   38   61                                                      
CONECT   38   37   39   62                                                      
CONECT   39   38   40   63                                                      
CONECT   40   39   41   64                                                      
CONECT   41   36   40   65                                                      
CONECT   42   34   43   44   66                                                 
CONECT   43   42   67   68   69                                                 
CONECT   44   42   45   70                                                      
CONECT   45   44   46   47                                                      
CONECT   46   45   71   72   73                                                 
CONECT   47   45   48   74                                                      
CONECT   48   47   49   75                                                      
CONECT   49   48   50   51   76                                                 
CONECT   50   18   49   77                                                      
CONECT   51   49   52   53   78                                                 
CONECT   52   51   79   80   81                                                 
CONECT   53   51   54   82                                                      
CONECT   54   53                                                                
CONECT   55   32                                                                
CONECT   56   32                                                                
CONECT   57   32                                                                
CONECT   58   34                                                                
CONECT   59   35                                                                
CONECT   60   35                                                                
CONECT   61   37                                                                
CONECT   62   38                                                                
CONECT   63   39                                                                
CONECT   64   40                                                                
CONECT   65   41                                                                
CONECT   66   42                                                                
CONECT   67   43                                                                
CONECT   68   43                                                                
CONECT   69   43                                                                
CONECT   70   44                                                                
CONECT   71   46                                                                
CONECT   72   46                                                                
CONECT   73   46                                                                
CONECT   74   47                                                                
CONECT   75   48                                                                
CONECT   76   49                                                                
CONECT   77   50                                                                
CONECT   78   51                                                                
CONECT   79   52                                                                
CONECT   80   52                                                                
CONECT   81   52                                                                
CONECT   82   53   83   90                                                      
CONECT   83   82   84   86   91                                                 
CONECT   84   83   85                                                           
CONECT   85   84                                                                
CONECT   86   83   87   92   93                                                 
CONECT   87   86   88   94   95                                                 
CONECT   88   87   89   96                                                      
CONECT   89   88                                                                
CONECT   90   82                                                                
CONECT   91   83                                                                
CONECT   92   86                                                                
CONECT   93   86                                                                
CONECT   94   87                                                                
CONECT   95   87                                                                
CONECT   96   88   97   98                                                      
CONECT   97   96  103  104  105                                                 
CONECT   98   96   99  101                                                      
CONECT   99   98  100                                                           
CONECT  100   99                                                                
CONECT  101   98  102  106                                                      
CONECT  102  101  107  108  109                                                 
CONECT  103   97                                                                
CONECT  104   97                                                                
CONECT  105   97                                                                
CONECT  106  101                                                                
CONECT  107  102                                                                
CONECT  108  102                                                                
CONECT  109  102                                                                
MASTER      136    0    4    0    0    0    0    6   54    1   95    1          
END