HEADER    ANTIBIOTIC                              18-JUN-03   1UGT              
TITLE     STRUCTURAL STUDIES OF CU(I)-BLEOMYCIN                                 
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: BLEOMYCIN A2;                                              
COMPND   3 CHAIN: A;                                                            
COMPND   4 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 SYNTHETIC: YES                                                       
KEYWDS    METAL COMPLEX, ANTIBIOTIC                                             
EXPDTA    SOLUTION NMR                                                          
MDLTYP    MINIMIZED AVERAGE                                                     
AUTHOR    T.E.LEHMANN                                                           
REVDAT   4   27-DEC-23 1UGT    1       REMARK                                   
REVDAT   3   23-MAR-22 1UGT    1       REMARK LINK                              
REVDAT   2   24-FEB-09 1UGT    1       VERSN                                    
REVDAT   1   27-APR-04 1UGT    0                                                
JRNL        AUTH   T.E.LEHMANN                                                  
JRNL        TITL   STRUCTURAL STUDY OF COPPER(I)-BLEOMYCIN.                     
JRNL        REF    J.BIOL.INORG.CHEM.            V.   9   323 2004              
JRNL        REFN                   ISSN 0949-8257                               
JRNL        PMID   15015041                                                     
JRNL        DOI    10.1007/S00775-004-0530-7                                    
REMARK   2                                                                      
REMARK   2 RESOLUTION. NOT APPLICABLE.                                          
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : XWINNMR 2.5, DISCOVER 2003                           
REMARK   3   AUTHORS     : BRUKER (XWINNMR), ACCELRYS (DISCOVER)                
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: THE STRUCTURE IS BASED ON A TOTAL OF 40   
REMARK   3  NON-TRIVIAL NOE-DERIVED DISTANCE CONSTRAINTS                        
REMARK   4                                                                      
REMARK   4 1UGT COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 24-JUN-03.                  
REMARK 100 THE DEPOSITION ID IS D_1000005807.                                   
REMARK 210                                                                      
REMARK 210 EXPERIMENTAL DETAILS                                                 
REMARK 210  EXPERIMENT TYPE                : NMR                                
REMARK 210  TEMPERATURE           (KELVIN) : 278                                
REMARK 210  PH                             : 8.1                                
REMARK 210  IONIC STRENGTH                 : 5MM                                
REMARK 210  PRESSURE                       : AMBIENT                            
REMARK 210  SAMPLE CONTENTS                : 5MM CU(I)BLM 1H, 90% H2O, 10%      
REMARK 210                                   D2O; 5MM CU(I)BLM, 100% D2O        
REMARK 210                                                                      
REMARK 210  NMR EXPERIMENTS CONDUCTED      : 2D NOESY                           
REMARK 210  SPECTROMETER FIELD STRENGTH    : 500 MHZ                            
REMARK 210  SPECTROMETER MODEL             : DRX                                
REMARK 210  SPECTROMETER MANUFACTURER      : BRUKER                             
REMARK 210                                                                      
REMARK 210  STRUCTURE DETERMINATION.                                            
REMARK 210   SOFTWARE USED                 : NMRPIPE 2002, DISCOVER 2003        
REMARK 210   METHOD USED                   : MOLECULAR DYNAMICS                 
REMARK 210                                                                      
REMARK 210 CONFORMERS, NUMBER CALCULATED   : 10                                 
REMARK 210 CONFORMERS, NUMBER SUBMITTED    : 1                                  
REMARK 210 CONFORMERS, SELECTION CRITERIA  : STRUCTURES WITH THE LOWEST         
REMARK 210                                   ENERGY                             
REMARK 210                                                                      
REMARK 210 BEST REPRESENTATIVE CONFORMER IN THIS ENSEMBLE : 1                   
REMARK 210                                                                      
REMARK 210 REMARK: THIS STRUCTURE WAS DETERMINED USING STANDARD 2D HOMONUCEAR   
REMARK 210  TECHNIQUES.                                                         
REMARK 215                                                                      
REMARK 215 NMR STUDY                                                            
REMARK 215 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM SOLUTION           
REMARK 215 NMR DATA.  PROTEIN DATA BANK CONVENTIONS REQUIRE THAT                
REMARK 215 CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES ON              
REMARK 215 THESE RECORDS ARE MEANINGLESS.                                       
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 610                                                                      
REMARK 610 MISSING HETEROATOM                                                   
REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 610 I=INSERTION CODE):                                                   
REMARK 610   M RES C SSEQI                                                      
REMARK 610     BLM A    1                                                       
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CO A  10  CO                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 BLM A   1   NC                                                     
REMARK 620 2 BLM A   1   NB   77.7                                              
REMARK 620 3 BLM A   1   NG   82.3 121.3                                        
REMARK 620 4 BLM A   1   NJ  113.8 114.4 124.2                                  
REMARK 620 N                    1     2     3                                   
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE BLM A 1                   
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CO A 10                   
HET    BLM  A   1     139                                                       
HET     CO  A  10       1                                                       
HETNAM     BLM BLEOMYCIN A2                                                     
HETNAM      CO COBALT (II) ION                                                  
HETSYN     BLM N1-[3-(DIMETHYLSULFONIO)-PROPYL]BLEOMYCINAMIDE                   
FORMUL   1  BLM    C55 H85 N17 O21 S3                                           
FORMUL   2   CO    CO 2+                                                        
LINK         NC  BLM A   1                CO    CO A  10     1555   1555  2.01  
LINK         NB  BLM A   1                CO    CO A  10     1555   1555  2.02  
LINK         NG  BLM A   1                CO    CO A  10     1555   1555  2.03  
LINK         NJ  BLM A   1                CO    CO A  10     1555   1555  2.03  
SITE     1 AC1  1  CO A  10                                                     
SITE     1 AC2  1 BLM A   1                                                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
HETATM    1  NA  BLM A   1     -14.575  27.241   3.310  1.00  0.00           N  
HETATM    2  C2  BLM A   1     -13.444  28.824   4.723  1.00  0.00           C  
HETATM    3  C1  BLM A   1     -13.593  28.128   3.387  1.00  0.00           C  
HETATM    4  O1  BLM A   1     -12.872  28.395   2.437  1.00  0.00           O  
HETATM    5  NC  BLM A   1     -14.299  31.063   5.490  1.00  0.00           N  
HETATM    6  C3  BLM A   1     -14.661  29.704   5.003  1.00  0.00           C  
HETATM    7  NB  BLM A   1     -12.253  29.696   4.908  1.00  0.00           N  
HETATM    8  ND  BLM A   1     -17.324  32.877   7.083  1.00  0.00           N  
HETATM    9  C5  BLM A   1     -15.337  33.392   5.829  1.00  0.00           C  
HETATM   10  C4  BLM A   1     -16.148  33.472   7.084  1.00  0.00           C  
HETATM   11  O4  BLM A   1     -15.765  34.104   8.049  1.00  0.00           O  
HETATM   12  C8  BLM A   1     -15.787  32.472   1.347  1.00  0.00           C  
HETATM   13  C9  BLM A   1     -14.517  32.756   0.987  1.00  0.00           C  
HETATM   14  C10 BLM A   1     -13.466  32.749   2.050  1.00  0.00           C  
HETATM   15  NG  BLM A   1     -13.811  32.376   3.231  1.00  0.00           N  
HETATM   16  C7  BLM A   1     -15.206  32.193   3.579  1.00  0.00           C  
HETATM   17  NE  BLM A   1     -16.157  32.217   2.724  1.00  0.00           N  
HETATM   18  C6  BLM A   1     -15.329  32.038   5.087  1.00  0.00           C  
HETATM   19  NF  BLM A   1     -16.890  32.395   0.486  1.00  0.00           N  
HETATM   20  CA  BLM A   1     -14.104  33.056  -0.428  1.00  0.00           C  
HETATM   21  C12 BLM A   1     -12.061  33.186   1.764  1.00  0.00           C  
HETATM   22  O12 BLM A   1     -11.422  32.932   0.751  1.00  0.00           O  
HETATM   23  NH  BLM A   1     -11.555  33.861   2.806  1.00  0.00           N  
HETATM   24  C13 BLM A   1     -10.205  34.416   3.008  1.00  0.00           C  
HETATM   25  C30 BLM A   1      -8.906  33.790   2.597  1.00  0.00           C  
HETATM   26  O30 BLM A   1      -7.992  34.440   2.107  1.00  0.00           O  
HETATM   27  C14 BLM A   1     -10.155  34.907   4.459  1.00  0.00           C  
HETATM   28  C27 BLM A   1     -10.516  33.928   5.553  1.00  0.00           C  
HETATM   29  OH1 BLM A   1     -10.845  36.116   4.713  1.00  0.00           O  
HETATM   30  NJ  BLM A   1     -11.452  32.855   5.887  1.00  0.00           N  
HETATM   31  C28 BLM A   1      -9.858  34.147   6.661  1.00  0.00           C  
HETATM   32  C29 BLM A   1     -11.389  32.705   7.162  1.00  0.00           C  
HETATM   33  NI  BLM A   1     -10.350  33.417   7.710  1.00  0.00           N  
HETATM   34  NK  BLM A   1      -8.868  32.516   2.925  1.00  0.00           N  
HETATM   35  C34 BLM A   1      -8.488  30.434   5.137  1.00  0.00           C  
HETATM   36  C36 BLM A   1      -9.004  29.085   5.582  1.00  0.00           C  
HETATM   37  O36 BLM A   1      -9.856  28.485   4.933  1.00  0.00           O  
HETATM   38  OH2 BLM A   1      -7.056  29.347   3.524  1.00  0.00           O  
HETATM   39  C31 BLM A   1      -7.647  31.694   3.012  1.00  0.00           C  
HETATM   40  CB  BLM A   1      -6.898  31.571   1.671  1.00  0.00           C  
HETATM   41  C33 BLM A   1      -8.054  30.351   3.654  1.00  0.00           C  
HETATM   42  CC  BLM A   1      -7.470  31.183   6.024  1.00  0.00           C  
HETATM   43  NL  BLM A   1      -8.485  28.559   6.822  1.00  0.00           N  
HETATM   44  C37 BLM A   1      -9.414  28.423   7.974  1.00  0.00           C  
HETATM   45  C40 BLM A   1     -10.841  28.010   7.671  1.00  0.00           C  
HETATM   46  O40 BLM A   1     -11.727  28.827   7.462  1.00  0.00           O  
HETATM   47  C38 BLM A   1      -9.327  29.728   8.774  1.00  0.00           C  
HETATM   48  OH3 BLM A   1      -7.971  29.987   9.112  1.00  0.00           O  
HETATM   49  CD  BLM A   1     -10.137  29.657  10.059  1.00  0.00           C  
HETATM   50  NM  BLM A   1     -11.067  26.707   7.639  1.00  0.00           N  
HETATM   51  O59 BLM A   1      -9.660  39.672   7.668  1.00  0.00           O  
HETATM   52  O58 BLM A   1     -12.653  37.742   6.885  1.00  0.00           O  
HETATM   53  C61 BLM A   1      -8.600  36.884   8.485  1.00  0.00           C  
HETATM   54  O61 BLM A   1      -8.792  37.528   9.744  1.00  0.00           O  
HETATM   55  O56 BLM A   1     -12.060  38.337   4.367  1.00  0.00           O  
HETATM   56  C60 BLM A   1      -9.707  37.176   7.453  1.00  0.00           C  
HETATM   57  O62 BLM A   1      -9.151  37.058   6.154  1.00  0.00           O  
HETATM   58  C63 BLM A   1     -10.054  37.276   5.080  1.00  0.00           C  
HETATM   59  C57 BLM A   1     -10.966  38.487   5.236  1.00  0.00           C  
HETATM   60  C58 BLM A   1     -11.586  38.655   6.597  1.00  0.00           C  
HETATM   61  C59 BLM A   1     -10.458  38.499   7.582  1.00  0.00           C  
HETATM   62  C69 BLM A   1     -13.225  38.551   2.434  1.00  0.00           C  
HETATM   63  C68 BLM A   1     -12.758  37.130   2.004  1.00  0.00           C  
HETATM   64  C67 BLM A   1     -11.547  37.338   1.063  1.00  0.00           C  
HETATM   65  C65 BLM A   1     -10.442  37.936   1.945  1.00  0.00           C  
HETATM   66  O64 BLM A   1     -10.826  39.183   2.563  1.00  0.00           O  
HETATM   67  C64 BLM A   1     -12.091  39.177   3.257  1.00  0.00           C  
HETATM   68  O68 BLM A   1     -13.847  36.403   1.349  1.00  0.00           O  
HETATM   69  O67 BLM A   1     -11.136  36.108   0.468  1.00  0.00           O  
HETATM   70  O69 BLM A   1     -13.586  39.346   1.310  1.00  0.00           O  
HETATM   71  NQ  BLM A   1     -15.900  35.591   1.464  1.00  0.00           N  
HETATM   72  C70 BLM A   1     -14.830  35.959   2.125  1.00  0.00           C  
HETATM   73  O70 BLM A   1     -14.752  35.883   3.343  1.00  0.00           O  
HETATM   74  O66 BLM A   1      -8.513  39.001   0.779  1.00  0.00           O  
HETATM   75  C66 BLM A   1      -8.972  37.859   1.496  1.00  0.00           C  
HETATM   76  HA2 BLM A   1     -14.758  26.818   2.425  1.00  0.00           H  
HETATM   77  HA1 BLM A   1     -15.218  27.147   4.067  1.00  0.00           H  
HETATM   78  H2  BLM A   1     -13.397  28.016   5.481  1.00  0.00           H  
HETATM   79  HNC BLM A   1     -14.198  31.033   6.492  1.00  0.00           H  
HETATM   80  H3E BLM A   1     -15.237  29.786   4.054  1.00  0.00           H  
HETATM   81  H3X BLM A   1     -15.317  29.192   5.727  1.00  0.00           H  
HETATM   82  HB1 BLM A   1     -11.902  29.563   5.846  1.00  0.00           H  
HETATM   83  HB2 BLM A   1     -11.478  29.366   4.351  1.00  0.00           H  
HETATM   84  HD2 BLM A   1     -17.903  33.004   7.884  1.00  0.00           H  
HETATM   85  HD1 BLM A   1     -17.716  32.608   6.206  1.00  0.00           H  
HETATM   86  H5E BLM A   1     -15.757  34.163   5.157  1.00  0.00           H  
HETATM   87  H5X BLM A   1     -14.309  33.734   6.046  1.00  0.00           H  
HETATM   88  H6  BLM A   1     -16.299  31.562   5.296  1.00  0.00           H  
HETATM   89  HF2 BLM A   1     -17.083  31.466   0.143  1.00  0.00           H  
HETATM   90  HF1 BLM A   1     -17.722  32.842   0.847  1.00  0.00           H  
HETATM   91  HAA BLM A   1     -14.961  33.059  -1.124  1.00  0.00           H  
HETATM   92  HAB BLM A   1     -13.612  34.043  -0.489  1.00  0.00           H  
HETATM   93  HAC BLM A   1     -13.390  32.293  -0.784  1.00  0.00           H  
HETATM   94  H13 BLM A   1     -10.166  35.248   2.336  1.00  0.00           H  
HETATM   95  H14 BLM A   1      -9.131  35.258   4.694  1.00  0.00           H  
HETATM   96  H28 BLM A   1      -9.106  34.907   6.672  1.00  0.00           H  
HETATM   97  H29 BLM A   1     -11.959  32.119   7.871  1.00  0.00           H  
HETATM   98  HNI BLM A   1     -10.049  33.416   8.680  1.00  0.00           H  
HETATM   99  HNK BLM A   1      -9.722  32.279   3.370  1.00  0.00           H  
HETATM  100  H34 BLM A   1      -9.384  31.062   5.209  1.00  0.00           H  
HETATM  101  HO2 BLM A   1      -6.276  29.641   4.029  1.00  0.00           H  
HETATM  102  H31 BLM A   1      -6.929  32.216   3.674  1.00  0.00           H  
HETATM  103  HBA BLM A   1      -7.497  31.059   0.903  1.00  0.00           H  
HETATM  104  HBB BLM A   1      -5.962  30.995   1.801  1.00  0.00           H  
HETATM  105  HBC BLM A   1      -6.617  32.564   1.274  1.00  0.00           H  
HETATM  106  H33 BLM A   1      -8.927  29.989   3.070  1.00  0.00           H  
HETATM  107  HCB BLM A   1      -7.797  31.244   7.074  1.00  0.00           H  
HETATM  108  HCC BLM A   1      -6.479  30.702   5.983  1.00  0.00           H  
HETATM  109  HCA BLM A   1      -7.353  32.234   5.701  1.00  0.00           H  
HETATM  110  HNL BLM A   1      -7.859  29.276   7.158  1.00  0.00           H  
HETATM  111  H37 BLM A   1      -8.993  27.640   8.634  1.00  0.00           H  
HETATM  112  H38 BLM A   1      -9.696  30.565   8.130  1.00  0.00           H  
HETATM  113  HO3 BLM A   1      -7.689  29.359   9.797  1.00  0.00           H  
HETATM  114  HDB BLM A   1      -9.904  28.712  10.579  1.00  0.00           H  
HETATM  115  HDC BLM A   1      -9.875  30.499  10.721  1.00  0.00           H  
HETATM  116  HDA BLM A   1     -11.216  29.684   9.831  1.00  0.00           H  
HETATM  117  HNM BLM A   1     -10.344  26.071   7.903  1.00  0.00           H  
HETATM  118 HO59 BLM A   1      -8.841  39.420   8.120  1.00  0.00           H  
HETATM  119 HO58 BLM A   1     -13.197  37.699   6.078  1.00  0.00           H  
HETATM  120 H611 BLM A   1      -7.629  37.218   8.064  1.00  0.00           H  
HETATM  121 H612 BLM A   1      -8.542  35.779   8.629  1.00  0.00           H  
HETATM  122 HO61 BLM A   1      -7.930  37.588  10.185  1.00  0.00           H  
HETATM  123  H60 BLM A   1     -10.491  36.402   7.577  1.00  0.00           H  
HETATM  124  H63 BLM A   1      -9.354  37.544   4.271  1.00  0.00           H  
HETATM  125  H57 BLM A   1     -10.360  39.393   5.033  1.00  0.00           H  
HETATM  126  H58 BLM A   1     -11.981  39.688   6.650  1.00  0.00           H  
HETATM  127  H59 BLM A   1     -11.053  38.342   8.451  1.00  0.00           H  
HETATM  128  H69 BLM A   1     -14.115  38.443   3.087  1.00  0.00           H  
HETATM  129  H68 BLM A   1     -12.376  36.539   2.915  1.00  0.00           H  
HETATM  130  H67 BLM A   1     -11.795  38.065   0.260  1.00  0.00           H  
HETATM  131  H65 BLM A   1     -10.422  37.191   2.738  1.00  0.00           H  
HETATM  132  H64 BLM A   1     -12.301  40.150   3.755  1.00  0.00           H  
HETATM  133 HO67 BLM A   1     -11.841  35.874  -0.161  1.00  0.00           H  
HETATM  134 HO69 BLM A   1     -14.204  40.038   1.591  1.00  0.00           H  
HETATM  135 HNQ1 BLM A   1     -15.926  35.755   0.485  1.00  0.00           H  
HETATM  136 HNQ2 BLM A   1     -16.665  35.234   1.986  1.00  0.00           H  
HETATM  137 HO66 BLM A   1      -9.110  39.149   0.031  1.00  0.00           H  
HETATM  138 H661 BLM A   1      -8.813  36.965   0.864  1.00  0.00           H  
HETATM  139 H662 BLM A   1      -8.355  37.675   2.416  1.00  0.00           H  
HETATM  140 CO    CO A  10     -12.567  31.675   4.668  1.00  0.00          CO  
CONECT    1    3   76   77                                                      
CONECT    2    3    6    7   78                                                 
CONECT    3    1    2    4                                                      
CONECT    4    3                                                                
CONECT    5    6   18   79  140                                                 
CONECT    6    2    5   80   81                                                 
CONECT    7    2   82   83  140                                                 
CONECT    8   10   84   85                                                      
CONECT    9   10   18   86   87                                                 
CONECT   10    8    9   11                                                      
CONECT   11   10                                                                
CONECT   12   13   17   19                                                      
CONECT   13   12   14   20                                                      
CONECT   14   13   15   21                                                      
CONECT   15   14   16  140                                                      
CONECT   16   15   17   18                                                      
CONECT   17   12   16                                                           
CONECT   18    5    9   16   88                                                 
CONECT   19   12   89   90                                                      
CONECT   20   13   91   92   93                                                 
CONECT   21   14   22   23                                                      
CONECT   22   21                                                                
CONECT   23   21   24                                                           
CONECT   24   23   25   27   94                                                 
CONECT   25   24   26   34                                                      
CONECT   26   25                                                                
CONECT   27   24   28   29   95                                                 
CONECT   28   27   30   31                                                      
CONECT   29   27   58                                                           
CONECT   30   28   32  140                                                      
CONECT   31   28   33   96                                                      
CONECT   32   30   33   97                                                      
CONECT   33   31   32   98                                                      
CONECT   34   25   39   99                                                      
CONECT   35   36   41   42  100                                                 
CONECT   36   35   37   43                                                      
CONECT   37   36                                                                
CONECT   38   41  101                                                           
CONECT   39   34   40   41  102                                                 
CONECT   40   39  103  104  105                                                 
CONECT   41   35   38   39  106                                                 
CONECT   42   35  107  108  109                                                 
CONECT   43   36   44  110                                                      
CONECT   44   43   45   47  111                                                 
CONECT   45   44   46   50                                                      
CONECT   46   45                                                                
CONECT   47   44   48   49  112                                                 
CONECT   48   47  113                                                           
CONECT   49   47  114  115  116                                                 
CONECT   50   45  117                                                           
CONECT   51   61  118                                                           
CONECT   52   60  119                                                           
CONECT   53   54   56  120  121                                                 
CONECT   54   53  122                                                           
CONECT   55   59   67                                                           
CONECT   56   53   57   61  123                                                 
CONECT   57   56   58                                                           
CONECT   58   29   57   59  124                                                 
CONECT   59   55   58   60  125                                                 
CONECT   60   52   59   61  126                                                 
CONECT   61   51   56   60  127                                                 
CONECT   62   63   67   70  128                                                 
CONECT   63   62   64   68  129                                                 
CONECT   64   63   65   69  130                                                 
CONECT   65   64   66   75  131                                                 
CONECT   66   65   67                                                           
CONECT   67   55   62   66  132                                                 
CONECT   68   63   72                                                           
CONECT   69   64  133                                                           
CONECT   70   62  134                                                           
CONECT   71   72  135  136                                                      
CONECT   72   68   71   73                                                      
CONECT   73   72                                                                
CONECT   74   75  137                                                           
CONECT   75   65   74  138  139                                                 
CONECT   76    1                                                                
CONECT   77    1                                                                
CONECT   78    2                                                                
CONECT   79    5                                                                
CONECT   80    6                                                                
CONECT   81    6                                                                
CONECT   82    7                                                                
CONECT   83    7                                                                
CONECT   84    8                                                                
CONECT   85    8                                                                
CONECT   86    9                                                                
CONECT   87    9                                                                
CONECT   88   18                                                                
CONECT   89   19                                                                
CONECT   90   19                                                                
CONECT   91   20                                                                
CONECT   92   20                                                                
CONECT   93   20                                                                
CONECT   94   24                                                                
CONECT   95   27                                                                
CONECT   96   31                                                                
CONECT   97   32                                                                
CONECT   98   33                                                                
CONECT   99   34                                                                
CONECT  100   35                                                                
CONECT  101   38                                                                
CONECT  102   39                                                                
CONECT  103   40                                                                
CONECT  104   40                                                                
CONECT  105   40                                                                
CONECT  106   41                                                                
CONECT  107   42                                                                
CONECT  108   42                                                                
CONECT  109   42                                                                
CONECT  110   43                                                                
CONECT  111   44                                                                
CONECT  112   47                                                                
CONECT  113   48                                                                
CONECT  114   49                                                                
CONECT  115   49                                                                
CONECT  116   49                                                                
CONECT  117   50                                                                
CONECT  118   51                                                                
CONECT  119   52                                                                
CONECT  120   53                                                                
CONECT  121   53                                                                
CONECT  122   54                                                                
CONECT  123   56                                                                
CONECT  124   58                                                                
CONECT  125   59                                                                
CONECT  126   60                                                                
CONECT  127   61                                                                
CONECT  128   62                                                                
CONECT  129   63                                                                
CONECT  130   64                                                                
CONECT  131   65                                                                
CONECT  132   67                                                                
CONECT  133   69                                                                
CONECT  134   70                                                                
CONECT  135   71                                                                
CONECT  136   71                                                                
CONECT  137   74                                                                
CONECT  138   75                                                                
CONECT  139   75                                                                
CONECT  140    5    7   15   30                                                 
MASTER       96    0    2    0    0    0    2    6   76    0  140    0          
END