*HEADER    DNA/RNA HYBRID                          23-JUL-03   1OKF
*TITLE     NMR STRUCTURE OF AN ALPHA-L-LNA:RNA HYBRID
*COMPND    MOL_ID: 1;
*COMPND   2 MOLECULE: 5'-D(*CP*ATLP*GP*AP*ATLP*AP*ATLP*GP*CP)-3';
*COMPND   3 SYNONYM: ALPHA-L-LNA;
*COMPND   4 CHAIN: A;
*COMPND   5 OTHER_DETAILS: ALPHA-L-LNA THYMINE MODIFICATIONS AT
*COMPND   6  POSITIONS 2, 5 AND 7;
*COMPND   7 MOL_ID: 2;
*COMPND   8 MOLECULE: 5'-R(*GP*CP*AP*UP*AP*UP*CP*AP*GP)-3';
*COMPND   9 CHAIN: B
*SOURCE    MOL_ID: 1;
*SOURCE   2 SYNTHETIC: YES;
*SOURCE   3 MOL_ID: 2;
*SOURCE   4 SYNTHETIC: YES
*KEYWDS    ALPHA-L-LNA, LNA, RNA, NMR, RNASE H, LOCKED NUCLEIC ACID
*EXPDTA    NMR, 20 STRUCTURES
*AUTHOR    J.T.NIELSEN,P.C.STEIN,M.PETERSEN
*REVDAT   1   09-OCT-03 1OKF    0




#
# NMR restraints from NOESY spectra recorded in D2O
#
  atom1  residue1  atom2  residue2  Lower Bound  Upper Bound
   1H2*         1    H1*         1         2.97         3.59
   2H2*         1    H1*         1         2.22          2.7
    H3*         1    H1*         1         3.67         4.51
    H3*         1   1H2*         1         2.32         2.84
    H3*         1   2H2*         1         2.82         3.42
    H4*         1   1H2*         1         3.81         4.79
    H4*         1   2H2*         1         3.87         4.69
     H5         1    H1*         1         4.79         6.23
     H5         1   1H2*         1         3.56         4.36
     H5         1   2H2*         1         4.33         5.89
     H5         1    H3*         1         4.63         5.99
     H5         1    H4*         1         5.07         6.33
     H6         1    H1*         1         3.49         4.23
     H6         1   1H2*         1         2.07         2.55
     H6         1   2H2*         1         2.95         3.57
     H6         1    H3*         1         3.34         4.06
    H5*         1    H1*         1          4.7         6.48
    H5*         1   1H2*         1         3.96         5.32
    H5*         1   2H2*         1         4.57         6.51
    H5*         1    H3*         1         3.05         4.19
    H5*         1     H5         1         4.94         6.68
    H5*         1     H6         1         3.81         5.11
    H1*         2    H1*         1         3.97         4.85
    H1*         2   1H2*         1         4.97         6.27
    H1*         2   2H2*         1         4.59         5.65
    H1*         2     H6         1         5.75         7.17
   1H2*         2    H1*         1          4.9         6.11
   1H2*         2   1H2*         1          6.2         7.74
   1H2*         2   2H2*         1         5.53         6.89
    H3*         2    H1*         1         4.47         5.45
    H3*         2   1H2*         1         5.47         6.83
    H3*         2   2H2*         1         5.17         6.75
   1H5*         2   2H2*         1         4.01         4.89
     H6         2    H1*         1         3.45         4.19
     H6         2   1H2*         1         3.08         4.18
     H6         2   2H2*         1         2.64         3.32
     H6         2    H3*         1         4.19         5.33
     H6         2     H5         1         4.68         5.88
     H6         2     H6         1         4.12         5.24
     H6         2    H5*         1         5.65         8.41
   2H9*         2   2H2*         1         3.49         4.27
    H5M         2    H1*         1         4.38         6.76
    H5M         2   1H2*         1         3.32         5.02
    H5M         2   2H2*         1          3.5         5.28
    H5M         2    H3*         1          4.3         6.76
    H5M         2    H4*         1         5.22          7.5
    H5M         2     H5         1         2.83         4.39
    H5M         2     H6         1          3.3         4.98
    H5M         2    H5*         1         5.28         8.46
    H3*         2    H1*         2         1.92         2.44
   1H5*         2    H1*         2         3.92         4.88
   1H5*         2   1H2*         2         4.47         5.57
   2H5*         2    H1*         2          4.8         6.32
   2H5*         2   1H2*         2         4.48         5.92
     H6         2    H1*         2         3.61         4.41
     H6         2   1H2*         2         4.16         5.14
     H6         2    H3*         2         4.31         5.59
    H5M         2    H1*         2         4.87         7.35
    H5M         2   1H2*         2         5.28         7.58
    H5M         2    H3*         2         5.15         7.43
    H5M         2   1H9*         2         3.59         5.47
    H5M         2   2H9*         2         4.07         6.43
     H8         3   2H2*         1         6.23         7.77
    H1*         3   1H2*         2         4.25         5.17
    H1*         3    H3*         2         5.61         6.99
   1H2*         3    H1*         2          5.5         6.86
   1H2*         3   1H2*         2         4.14         5.18
   1H2*         3    H3*         2         5.91         7.37
   2H2*         3    H1*         2         5.61         6.99
   2H2*         3   1H2*         2         4.55         5.71
   2H2*         3    H3*         2         6.87         8.57
    H3*         3    H1*         2         5.04         6.28
    H3*         3   1H2*         2         4.11         5.03
    H3*         3     H6         2          5.6         7.32
    H4*         3    H1*         2          5.0         6.24
    H4*         3   1H2*         2         3.91         4.73
   2H5*         3    H1*         2         4.17         5.15
   2H5*         3   1H2*         2         3.49         4.25
   2H5*         3    H3*         2         5.04         6.36
   2H5*         3     H6         2         5.16          6.5
   1H5*         3    H1*         2         4.19         5.15
   1H5*         3   1H2*         2         3.01         3.73
   1H5*         3    H3*         2         4.46          5.7
     H8         3    H1*         2         3.59         4.43
     H8         3   1H2*         2          2.2         2.68
     H8         3    H3*         2         4.12         5.24
     H8         3     H6         2         4.69         5.93
     H8         3    H5M         2         5.19         7.59
     H8         3    H9*         2         5.25         7.39
   1H2*         3    H1*         3         2.81         3.37
   2H2*         3    H1*         3         2.12         2.58
    H3*         3    H1*         3         3.58         4.38
    H3*         3   1H2*         3         2.53         3.15
    H3*         3   2H2*         3          3.0         3.64
    H4*         3   2H2*         3         3.27         4.41
     H8         3    H1*         3         3.74         4.62
     H8         3   1H2*         3         2.83         3.53
     H8         3   2H2*         3         3.59         4.39
     H8         3    H3*         3         3.66         4.44
     H8         3    H4*         3         3.98         4.92
     H8         3   2H5*         3         3.65         4.67
     H8         3   1H5*         3         3.28         3.98
     H8         4   1H2*         2         5.68         7.08
    H1*         4    H1*         3         5.14          6.4
    H1*         4   1H2*         3         5.27         6.57
    H1*         4   2H2*         3         4.71         6.05
    H1*         4    H3*         3         6.06         7.56
   1H2*         4    H1*         3         4.84         6.04
   1H2*         4   1H2*         3         4.58         5.82
   1H2*         4    H3*         3         5.15         6.43
   1H2*         4     H8         3         6.03         7.53
   2H2*         4    H1*         3         5.56         6.94
   2H2*         4   1H2*         3         4.98         6.38
   2H2*         4   2H2*         3         4.58         5.62
   2H2*         4    H3*         3         5.69         7.09
   2H2*         4     H8         3          7.0         9.32
    H3*         4    H1*         3         4.92         6.14
    H3*         4   1H2*         3         5.17         6.45
    H3*         4   2H2*         3         4.38         5.56
    H3*         4    H3*         3         5.69         7.09
    H4*         4    H1*         3         5.67         7.41
    H4*         4   1H2*         3         4.68         5.82
     H8         4    H1*         3         3.74         4.58
     H8         4   1H2*         3         3.04         3.76
     H8         4   2H2*         3         2.86         3.56
     H8         4    H3*         3         3.92         4.76
     H8         4    H4*         3         4.74         6.12
     H8         4     H8         3         4.67         6.15
     H2         4    H1*         4         4.62         5.72
   1H2*         4    H1*         4         2.74         3.32
   1H2*         4     H2         4          6.0         7.64
   2H2*         4    H1*         4         2.22         2.76
   2H2*         4     H2         4         5.63         7.03
    H3*         4    H1*         4         3.42         4.14
    H3*         4     H2         4          6.0         8.82
    H3*         4   1H2*         4         2.37         2.97
    H3*         4   2H2*         4         2.64         3.24
    H4*         4    H1*         4         2.79         3.81
    H4*         4   1H2*         4         3.66         4.46
    H4*         4   2H2*         4         3.72         4.54
   1H5*         4    H1*         4          5.0         6.77
   1H5*         4   1H2*         4         4.42         5.86
   1H5*         4   2H2*         4         4.34         5.76
   2H5*         4    H1*         4         4.31         5.73
   2H5*         4   1H2*         4         4.33         5.97
   2H5*         4   2H2*         4         4.37         5.57
   2H5*         4    H3*         4         2.87         3.49
     H8         4    H1*         4         3.54          4.3
     H8         4   1H2*         4         2.26         2.86
     H8         4   2H2*         4         2.88          3.5
     H8         4    H3*         4         3.44          4.2
     H8         4    H4*         4         4.29         5.43
     H8         4   1H5*         4         4.69         6.19
     H8         4   2H5*         4         4.24          5.4
     H6         5   1H2*         3         5.62          7.0
     H6         5   2H2*         3         5.39         6.87
    H5M         5    H1*         3         5.59         7.97
    H5M         5   1H2*         3         4.89         7.11
    H5M         5   2H2*         3         4.64         6.82
    H5M         5    H3*         3         5.51         7.87
    H5M         5    H4*         3         6.53         9.15
    H5M         5     H8         3          5.7         8.12
    H1*         5    H1*         4         3.97         4.85
    H1*         5     H2         4         2.93         3.57
    H1*         5   1H2*         4         5.06         6.32
    H1*         5   2H2*         4         4.76          6.2
    H1*         5    H3*         4         5.79         7.22
    H1*         5     H8         4         5.67         7.07
   1H2*         5    H1*         4         5.13         6.61
   1H2*         5     H2         4         4.43         5.63
   1H2*         5   1H2*         4         5.78          7.2
   1H2*         5   2H2*         4         5.35         6.67
   1H5*         5   1H2*         4         4.91         6.47
   1H5*         5   2H2*         4         3.92         5.22
   2H5*         5    H1*         4         5.07         6.67
   2H5*         5   1H2*         4         6.46          8.4
     H6         5    H1*         4         3.31         4.03
     H6         5   1H2*         4         3.13         3.83
     H6         5   2H2*         4         2.65         3.39
     H6         5    H3*         4         4.06         5.26
     H6         5     H8         4         3.87         4.71
   1H9*         5     H8         4         6.32         8.22
    H5M         5    H1*         4         4.18         6.46
    H5M         5     H2         4         5.65         8.05
    H5M         5   1H2*         4         3.38         5.08
    H5M         5   2H2*         4         3.41         5.15
    H5M         5    H3*         4         4.43         7.07
    H5M         5    H4*         4         5.46         7.82
    H5M         5     H8         4         2.89         4.49
    H9*         5    H1*         4         4.16         6.02
    H9*         5   1H2*         4         5.01         7.09
    H9*         5   2H2*         4         3.45         5.15
     H6         5    H1*         5         3.77         5.03
     H6         5   1H2*         5         4.75         5.93
     H6         5    H3*         5         5.46         6.82
     H6         5   1H5*         5          5.2         6.82
    H5M         5    H1*         5         4.97         7.41
    H5M         5   1H2*         5         5.46         7.82
    H5M         5   1H5*         5          5.5         7.86
     H8         6   2H2*         4         5.96         7.44
    H1*         6    H1*         5         5.51         6.85
    H1*         6   1H2*         5         4.71         6.13
   1H2*         6    H1*         5         5.58         6.96
   1H2*         6   1H2*         5         4.13         5.17
   2H2*         6    H1*         5         5.71         7.13
   2H2*         6   1H2*         5         4.57         5.69
   1H5*         6    H1*         5         4.99         6.61
   2H5*         6    H1*         5         4.57         6.03
     H8         6    H1*         5         3.94         4.92
     H8         6     H6         5         4.84         6.38
     H8         6    H5M         5         5.28         7.84
     H2         6    H1*         6         4.52         5.52
   1H2*         6    H1*         6         2.95         3.59
   1H2*         6     H2         6         5.58         6.96
   2H2*         6    H1*         6         2.39         2.97
   2H2*         6     H2         6         5.61         6.99
    H4*         6     H2         6         5.93         7.39
    H4*         6   1H2*         6         3.72          4.5
    H4*         6   2H2*         6         3.47         4.23
   2H5*         6    H1*         6         4.95         6.51
   2H5*         6   1H2*         6         3.89         4.71
   2H5*         6   2H2*         6         4.38         5.88
     H8         6    H1*         6         3.79         4.59
     H8         6   1H2*         6         2.67         3.37
     H8         6   2H2*         6         3.36          4.1
    H5M         7    H1*         5         6.07         8.57
    H5M         7   1H2*         5          4.9         7.34
    H1*         7    H1*         6         4.42          5.4
    H1*         7     H2         6          3.0         3.66
    H1*         7   1H2*         6         5.16         6.64
    H1*         7   2H2*         6         4.89         6.33
    H1*         7     H8         6         5.99         7.47
   1H2*         7    H1*         6         5.57         6.95
   1H2*         7     H2         6         4.41         5.83
   1H2*         7   2H2*         6         5.94          7.4
   1H5*         7     H2         6         5.76         7.18
   1H5*         7   1H2*         6         4.51         5.63
   1H5*         7   2H2*         6         3.84         5.12
   2H5*         7    H1*         6         5.29         6.93
   2H5*         7   1H2*         6         4.49         5.93
   2H5*         7   2H2*         6          4.1         5.44
     H6         7   1H2*         6          3.4         4.16
     H6         7   2H2*         6         2.86          3.6
    H5M         7    H1*         6         4.49         6.92
    H5M         7     H2         6         5.28         7.58
    H5M         7   1H2*         6         3.76         5.56
    H5M         7   2H2*         6         3.71         5.57
    H5M         7    H4*         6         5.56         7.94
    H5M         7     H8         6         3.28         4.98
   1H5*         7    H1*         7         4.18          5.3
   1H5*         7   1H2*         7          5.0         6.59
   2H5*         7    H1*         7         4.31         5.73
     H6         7    H1*         7         3.85         4.73
     H6         7   1H2*         7          4.6         5.96
     H6         7   1H5*         7         5.38         7.04
    H5M         7    H1*         7         4.93         7.26
    H5M         7   1H2*         7          5.6         7.98
    H5M         7   1H5*         7         5.46         7.82
    H9*         7    H5M         7          3.8         6.34
   1H2*         8     H2         6          7.0         9.41
     H8         8     H2         6         5.31         6.63
     H8         8   1H2*         6         6.48         8.08
     H8         8   2H2*         6          6.0         7.48
    H1*         8    H1*         7         5.08         6.34
    H1*         8   1H2*         7         4.26         5.22
   1H2*         8    H1*         7         5.61         6.99
   1H2*         8   1H2*         7         4.31         5.33
   1H2*         8     H6         7         6.75         8.41
   2H2*         8    H1*         7         5.79         7.23
   2H2*         8   1H2*         7         4.64         6.04
    H3*         8   1H2*         7         4.31         5.37
    H4*         8    H1*         7         4.87         6.07
    H4*         8   1H2*         7         4.08         5.08
   1H5*         8    H1*         7         4.17         5.15
   1H5*         8   1H2*         7         3.06         3.78
     H8         8    H1*         7         3.67         4.55
     H8         8   1H2*         7          2.3         2.82
     H8         8     H6         7         4.55         5.77
     H8         8    H5M         7         5.07         7.43
   1H2*         8    H1*         8         2.64         3.18
   2H2*         8    H1*         8          1.9         2.36
    H3*         8    H1*         8         3.51         4.23
    H3*         8   1H2*         8         2.59         3.23
    H4*         8    H1*         8         2.98         3.62
    H4*         8   1H2*         8         3.54         4.32
    H4*         8   2H2*         8         3.04         3.74
     H8         8    H1*         8         3.72          4.5
     H8         8   1H2*         8         3.04          3.8
     H8         8   2H2*         8         3.76         4.62
     H8         8    H3*         8         3.36         4.06
     H8         8    H4*         8         4.02         4.94
     H8         8   1H5*         8         3.08         3.76
     H5         9   1H2*         7         5.55         6.93
     H6         9   1H2*         7         5.36         6.78
    H1*         9   1H2*         8         4.88         6.42
    H1*         9   2H2*         8         4.72         5.88
    H1*         9    H3*         8         5.53         6.89
    H1*         9    H4*         8         6.08         7.58
    H1*         9     H8         8         6.09         7.59
   1H2*         9    H1*         8         5.01         6.37
   1H2*         9   1H2*         8         5.08         6.34
   1H2*         9   2H2*         8         4.55         5.71
   1H2*         9     H8         8         6.14         7.66
    H3*         9    H1*         8         4.99         6.53
    H3*         9   1H2*         8         4.18         5.66
     H5         9    H1*         8          4.2         5.34
     H5         9   1H2*         8         3.44         4.16
     H5         9   2H2*         8         3.61         4.37
     H5         9    H3*         8         3.96         4.92
     H5         9     H8         8         4.14         5.04
     H6         9    H1*         8         3.62         4.38
     H6         9   2H2*         8         2.95         3.63
     H6         9    H3*         8          3.6         4.36
   1H2*         9    H1*         9         2.45         2.99
   2H2*         9    H1*         9         1.62          2.1
    H3*         9    H1*         9          3.5         4.24
    H3*         9   2H2*         9         2.74         3.76
     H5         9    H1*         9         4.49         5.71
     H5         9   1H2*         9         3.76          4.6
     H5         9   2H2*         9          4.4         5.58
     H6         9   2H2*         9         3.29         3.97
    H4*        10    H1*        10         3.41         4.15
   1H5*        10    H1*        10          4.6         6.18
   2H5*        10    H1*        10          4.6         6.22
   2H5*        10    H3*        10         3.15         3.83
     H8        10    H1*        10         4.03         5.07
     H8        10   1H2*        10         4.12          5.0
     H8        10    H3*        10         3.42         4.14
     H8        10    H4*        10         4.39         5.73
     H8        10   1H5*        10         4.05         4.99
     H8        10   2H5*        10          3.8          4.6
     H5        11    H4*        10         5.18         6.46
     H5        11   1H5*        10         5.56         6.94
     H5        11   2H5*        10         5.11         6.51
     H5        11     H8        10         4.62          5.9
     H6        11    H4*        10         4.48         5.58
     H6        11   1H5*        10         5.05         6.47
     H6        11   2H5*        10         4.77         6.13
     H5        11    H3*        11         3.58          4.8
   2H5*        11     H5        11         4.96         6.18
     H2        12   1H2*         7         4.93         6.29
     H2        12    H5M         7         6.68         9.34
     H2        12    H1*         8         3.58         4.36
     H2        12   1H2*         8          5.2          6.6
     H2        12   2H2*         8         4.89         6.21
     H2        12    H4*         8         5.58         6.96
     H2        12     H8         8         4.92          6.3
    H1*        12    H1*        11         4.73         5.89
    H1*        12   1H2*        11         3.28         4.42
     H8        12    H1*        11         3.56         4.48
     H8        12     H5        11         4.93         6.63
     H8        12     H6        11         4.41         5.39
     H2        12    H1*        12          4.5         5.48
   1H2*        12    H1*        12         2.26         2.76
   1H2*        12     H2        12         4.68         5.96
   1H5*        12    H1*        12         3.96         4.96
   2H5*        12    H1*        12         4.48         5.58
     H8        12    H1*        12         3.68         4.44
    H1*        13     H2         6         5.08          6.3
    H1*        13    H1*         8         5.42         6.98
    H1*        13    H1*        12         4.94          6.5
    H1*        13     H2        12         3.08         3.72
    H1*        13   1H2*        12         3.85         4.69
   1H2*        13     H2        12         4.69         6.29
     H5        13    H1*        12         4.71         6.15
     H5        13     H2        12         4.81         5.99
     H5        13     H8        12          4.5         5.78
   2H5*        13    H1*        12         5.11         6.37
     H6        13    H1*        12          3.7         4.56
     H6        13     H2        12          5.0         6.41
     H6        13   1H2*        12         2.23         2.79
     H6        13    H3*        12         3.26          4.4
     H6        13   2H5*        12         5.24         6.54
     H6        13     H8        12         4.61         5.75
   1H2*        13    H1*        13         2.39         2.89
     H5        13    H1*        13         4.73         6.27
   2H5*        13    H1*        13         4.44         5.76
   2H5*        13     H5        13          4.5         5.62
     H6        13    H1*        13         3.58         4.34
     H6        13   1H5*        13         3.43         4.19
     H6        13   2H5*        13         3.33         4.09
    H1*        14     H2         6         3.08         3.74
   1H2*        14     H2         6         4.69         5.85
    H4*        14     H2         6         5.67         7.07
     H8        14     H2         6         5.13         6.51
    H1*        14    H1*         7          5.1         6.32
     H8        14     H2        12         5.56         6.94
    H1*        14    H1*        13         4.69         5.79
     H8        14    H1*        13          3.6         4.46
     H8        14     H5        13          4.8         5.98
     H8        14   2H5*        13         4.72         6.04
     H8        14     H6        13         4.23         5.17
     H2        14    H1*        14         4.54         5.74
     H8        14    H1*        14         3.63         4.39
     H8        14   2H5*        14         3.55         4.31
    H1*        15     H2         4         5.36         6.74
     H5        15     H2         4         5.87         7.31
    H1*        15    H1*         6          5.8         7.24
     H6        15     H2         6         5.78          7.2
    H1*        15    H1*        14         4.92         6.26
    H1*        15     H2        14         3.44         4.16
     H5        15    H1*        14         4.56          5.8
     H5        15     H2        14         5.06          6.3
     H5        15    H3*        14         3.66         4.58
     H5        15     H8        14         4.54         5.96
   2H5*        15    H1*        14         4.56         5.68
     H6        15    H1*        14         3.62         4.46
     H6        15     H2        14         4.87         6.07
     H6        15   2H5*        14         5.21         6.63
     H6        15     H8        14         4.59         5.91
   1H2*        15    H1*        15         2.47         3.01
     H5        15    H1*        15         4.71         5.97
   2H5*        15    H1*        15         4.59         6.11
   2H5*        15     H5        15         4.45         5.55
     H6        15    H1*        15         3.63         4.41
     H6        15   1H2*        15         3.65         4.45
     H6        15   2H5*        15         3.64          4.4
    H1*        16     H2         4          3.4         4.12
    H1*        16    H1*         5         5.29         6.61
     H6        16     H2        14         5.72         7.16
    H1*        16    H1*        15         4.65         5.79
    H1*        16   1H2*        15         3.74         4.54
     H5        16    H1*        15         4.29         5.49
     H5        16   1H2*        15         3.37         4.07
     H5        16     H5        15         4.15         5.73
     H5        16   2H5*        15         5.21         6.49
     H5        16     H6        15         4.16         5.08
   2H5*        16    H1*        15         5.11         6.55
     H6        16    H1*        15         3.69         4.59
     H6        16   1H2*        15         2.14          2.7
     H6        16     H5        15         5.13         6.63
     H6        16   2H5*        15         4.28         5.34
     H6        16     H6        15         4.41         5.51
   1H2*        16    H1*        16         2.41         2.91
    H4*        16    H1*        16         3.38          4.1
     H5        16   1H2*        16         4.37         5.63
   2H5*        16    H1*        16         4.31         5.51
   2H5*        16     H5        16         4.98         6.76
     H6        16    H1*        16          3.4         4.14
     H2        17    H1*         2         4.82         6.04
     H2        17   1H2*         2          5.0         6.44
     H2        17    H3*         2         6.04         7.54
     H2        17     H6         2         6.68         8.34
     H2        17    H5M         2         5.95         8.43
     H2        17    H1*         3         3.84         4.66
     H2        17   1H2*         3         5.63         7.03
     H2        17   2H2*         3         5.25         6.61
     H2        17    H4*         3         5.85         7.29
     H2        17     H8         3         4.85         5.93
    H1*        17    H1*        16         5.17         6.45
    H1*        17   1H2*        16         3.97         4.87
   1H2*        17     H5        16         5.51         6.87
    H3*        17     H5        16         5.53         7.23
     H8        17    H1*        16         3.59         4.33
     H8        17     H5        16         4.48         5.92
     H2        17    H1*        17         4.75         6.19
   1H2*        17    H1*        17         2.26         2.76
   1H2*        17     H2        17         4.85         6.41
    H3*        17    H1*        17         3.38         4.08
    H4*        17    H1*        17         3.31         3.99
   2H5*        17    H1*        17         4.55         6.09
     H8        17    H1*        17          3.6         4.36
     H8        18   1H2*        16         5.43         7.11
    H1*        18     H2        17         3.85         4.65
    H1*        18   1H2*        17         4.06         4.94
    H1*        18    H3*        17         5.02         6.26
   1H2*        18    H1*        17         5.37         6.69
   1H2*        18     H2        17          5.2         6.52
    H3*        18    H1*        17         4.52         5.54
    H3*        18     H2        17         5.57         6.95
   2H5*        18    H1*        17         5.19         6.47
   2H5*        18    H3*        17         4.58         5.72
   2H5*        18     H8        17         5.79         7.23
     H8        18    H1*        17         4.02         5.02
     H8        18     H2        17          4.9         6.12
     H8        18   1H2*        17         2.52          3.1
     H8        18    H3*        17         3.46         4.18
     H8        18   1H5*        17         5.56         6.94
     H8        18   2H5*        17         5.38          6.7
     H8        18     H8        17          4.7         6.12
    H3*        18    H1*        18         2.93         3.51
     H8        18    H1*        18         3.89         4.73
     H8        18   1H2*        18         2.86          3.9
     H8        18    H3*        18         2.68         3.24
#
# NMR restraints from NOESY spectra recorded in H2O
#
  atom1  residue1  atom2  residue2  Lower Bound  Upper Bound
     H2         4     H1         3         3.47         4.99
    1H6         4     H1         3         3.94          5.9
     H3         5     H2         4          3.8         5.84
     H3         5    1H6         4         4.03         6.05
     H3         5    H1*         5         4.22         6.32
     H3         5   1H2*         5         4.54         6.82
     H2         6     H3         5          4.2          6.3
    1H6         6     H3         5         3.96         6.38
     H8         6     H3         5         4.15         6.23
    H5M         7     H3         5         4.49         7.73
     H3         7    H1*         6         4.62         6.94
     H3         7     H2         6         3.57         5.19
     H3         7    1H6         6         4.02         6.02
     H3         7    2H6         6          3.2         4.56
     H3         7    H1*         7          4.2          6.3
     H1         8     H3         7         4.52         6.78
    H1*         8     H3         7          4.1         6.16
   1H5*         8     H3         7         4.59         6.89
     H8         8     H3         7         3.82         5.72
    H1*         9     H1         8         4.49         6.73
    1H4         9   1H2*         8         4.34         6.52
    2H4         9   2H2*         8         4.29         6.43
    2H4         9     H8         8         4.64         6.96
    1H4        11     H3         7         4.11         6.17
    1H4        11    H5M         7          4.7         8.04
    2H4        11     H3         7         4.25         6.37
    H1*        11     H1         8         4.59         6.89
    2H4        11     H1         8          3.3         4.74
     H5        11     H1         8         4.26         6.38
    1H4        11    2H4         9         3.99         5.99
    2H4        11    1H4         9          4.3         6.44
     H2        12     H3         7         2.34         3.38
    H1*        12     H1         8         3.83         5.65
     H2        12     H1         8         4.12         6.38
     H8        12     H1         8         4.42         6.64
     H3        13     H3         5         4.28         6.42
     H3        13     H2         6         2.39         3.57
     H3        13    2H6         6         2.95         4.25
    H1*        13     H3         7         4.28         6.42
     H3        13    H1*         7         4.19         6.29
     H3        13     H3         7         3.08          4.5
     H3        13    H5M         7         4.66         7.98
     H5        13     H3         7         4.84         7.26
     H6        13     H3         7         4.54         6.82
     H3        13     H2        12         3.52         5.04
     H3        13    H1*        13         3.99         6.13
     H3        13   1H2*        13         4.37         6.55
     H2        14     H3         5         2.28         3.32
     H2        14     H3        13         4.17         6.25
     H8        14     H3        13         4.43         6.65
     H3        15     H1         3         3.23         4.77
     H3        15     H2         4         2.46         3.68
    H1*        15     H3         5         4.22         6.32
     H3        15    H1*         5          4.3         6.46
     H3        15     H3         5          3.5         5.08
     H6        15     H3         5         4.87         7.31
     H3        15     H2        14         3.63         5.29
     H3        15    H1*        15          4.6          6.9
     H6        15     H3        15         4.33         6.49
    1H4        16    H5M         2         4.41         7.61
    2H4        16    H5M         2         4.37         7.55
    2H4        16     H1         3         3.07         4.37
     H6        16     H1         3          4.6          6.9
    H1*        16     H3        15         4.51         6.77
    1H4        16     H3        15         3.83         6.03
    1H4        16     H6        15         4.34          6.5
    2H4        16     H3        15          3.8         6.06
    2H4        16     H6        15         4.13         6.19
     H5        16     H3        15         4.13         6.19
    H1*        17     H1         3         3.67         5.67
     H2        17     H1         3          3.8         5.92
     H8        17     H1         3         4.33         6.49
#
# Watson-Crick base pairing restraints
#
  atom1  residue1  atom2  residue2  Lower Bound  Upper Bound
     O2         1    1H2        18         1.74         2.10
     N3         1     H1        18         1.74         2.10
    1H4         1     O6        18         1.74         2.10
     H3         2     N1        17         1.74         2.10
     O4         2    1H6        17         1.74         2.10
     O2        16    1H2         3         1.74         2.10
     N3        16     H1         3         1.74         2.10
    1H4        16     O6         3         1.74         2.10
     H3        15     N1         4         1.74         2.10
     O4        15    1H6         4         1.74         2.10
     H3         5     N1        14         1.74         2.10
     O4         5    1H6        14         1.74         2.10
     H3        13     N1         6         1.74         2.10
     O4        13    1H6         6         1.74         2.10
     H3         7     N1        12         1.74         2.10
     O4         7    1H6        12         1.74         2.10
     O2        11    1H2         8         1.74         2.10
     N3        11     H1         8         1.74         2.10
    1H4        11     O6         8         1.74         2.10
     O2         9    1H2        10         1.74         2.10
     N3         9     H1        10         1.74         2.10
    1H4         9     O6        10         1.74         2.10